CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044053
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Baculoviral IAP repeat-containing protein 6 
Protein Synonyms/Alias
  
Gene Name
 Birc6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
67VTSRGTIKVIDGTSGubiquitination[1]
523NPSLTNSKSEKTKEKubiquitination[1]
1624EKQQQLLKLQQQKAKubiquitination[1]
2179EDEAAAAKKPLNGKDubiquitination[1]
2253ALVEQMEKEKIQSNKubiquitination[1]
2265SNKGSSYKLLVEQAKubiquitination[1]
2272KLLVEQAKLKQATSKubiquitination[1]
3134FLDSGPNKAVDSTLKubiquitination[1]
3916VVVASGLKSQSKRAMubiquitination[1]
4016ITDPSLSKTDSFKRLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4854 AA 
Protein Sequence
MAAAAAEASG PSCSSAAAAA GAGAAGVSEW LVLRDGCMRC DADGLHSLSY HPALNAILAV 60
TSRGTIKVID GTSGATLQAS ALSAKPGGQV KCQYISAVDK VIFVDDYAVG CRKDLNGILL 120
LDTALQTPVS KQDDVVQLEL PVTEAQQLLS ACIEKIDVSS TEGYDLFITQ LKDGLKNTSH 180
ETAANHKVAK WATVTFHLPH HVLKSIASAI VNELKKINQN VAALPVASSV MDRLSYLLPS 240
ARPELGVGPG RSVDRALMYS EANRRETFTS WPHVGYRWAQ PDPMAQAGFY HQPASSGDDR 300
AMCFTCSVCL VCWEPTDEPW SEHERHSPNC PFVKGEHTQN VPLSVTLATS PAQLPSADGA 360
DRIACFGSGS CPQFLAAATK RGKICIWDVS KLMKVHLKFE INAYDPAIVQ QLILSGDPSS 420
GVDSRRPTLA WLEDSSSCSD IPKLEGDSDD LLEDSDSEEH SRSDSVTGHT SQKEAMEVSL 480
DITALSILQQ PEKLQWEIVA NVLEDTVKDL EELGANPSLT NSKSEKTKEK HQEQHNIPFP 540
CLLAGGLLTY KSPATSPISS NSHRSLDGLS RTQGESISEQ GSTDNESCTN SELNSPLVRR 600
TLPVLLLYSI KESDEKAGKI FSQMNNIMSK SLHDDGFTVP QIIEMELDNQ EQLLLQDPPV 660
TYIQQFADAA ASLTSPDSEK WNSVFPKPGA LVQCLRLPKF AEEETLCIDS ITPCADGIHL 720
LVGLRTCSVE SLSAINQVEA LNNLNKLNSA LCNRRKGDLE SNLAVVNGAN ISVIQHESPA 780
DVPEHLLIRP EQRNVVSGGY LVLYKMNYTT RIVTLEEEPV KIQHIKDPQD TITSLILLPP 840
DILDNREDDC EEPAEEMQLA SKNGIEREKK SDISTLGHLV VTTQGGYVKV LDLSNFEILA 900
KVEPPKKEGT EEQDTFVSVI YCSGTDRLCA CTKGGELHFL QIGGTCDDID EADILVDGSL 960
SKGIEPALEG SRPLSNPSSP GISGVELLVD QPFTLEILTS LVELTRFETL TPRFSATVPP 1020
CWVEVQQEQQ QRRHPQHLHQ QHHGDAAQHT RTWKLQTDSN SWDEHVFELV LPKACMVGHV 1080
DFKFVLNSNI TSVPQIQVTL LKNKAPGLGK ANALNIEVEH NGNPSLVDLN EEMHHMDVEE 1140
SQCLRLCPFL EDHKEDILCG PVWLASGLDL SGHAGMLTLT SPKLVKGMAG GKYRSFLIHV 1200
KAVSDRGAAD EMCSSGLRPV VRLPSLKQQG HKGYSLASLL AKVAAGKEKS SNVKNENAGG 1260
TRKSENLRGC DLLQEVSVTI RRFKKTSICK ERVQRCAMLQ FSEFHEKLLN TLCRRSDDGQ 1320
VTEHAQSLVL DALCWLAGVH SNGSGSSKEG NECLLSKTRK CLSDIVRVCF FEAGRSIAHK 1380
CARFLALCIS NGKCEPCQPG FGSVLLKALL DNMCFLPAAA TGGSVYWYFV LLNYVKDEDL 1440
AGCSTACAAL LTAVSRQLQD RLTPLEALLQ TRYGLYSSPF DPVLFDLEMS GSSWKTVYSS 1500
STAVQSDEID LSDVLSGNGR VSSCTAAEGS FTSLTGLLEV EPLHFTCVST SDGTRIERDD 1560
ASTFTVSSFG VPPAVGGLSS GTVGEASTAL SSAAQVALQS LSHAMASAEQ QLQVLQEKQQ 1620
QLLKLQQQKA KLEAKLHQTT AAAAAAASAA AAAAAGPVHN AVPSNPVAAP GFFIHPSDVI 1680
PPTPKTTPLF MTPPLTPPNE AVSVVINAEL AQLFPGSVID PPAVNLAAQN KNSSKSRMNP 1740
LGSGLALAIS HASHFLQPPP HQSIIIERMH SGARRFVTLD FGRPILLTDV LIPTCGDLAS 1800
LSIDIWTLGE EVDGRRLVVA TDISTHSLIL HDLIPPPVCR FMKITVIGRY GSTNARAKIP 1860
LGFYYGHSYI LPWESELKLM HDPLRGEGES ASQPEIDQHL AMMVALQEDI QCRYNLACHR 1920
LEALLQSIDL PPLNSANNAQ YFLRKPDKAV EEDSRVFSAY QDCIQLQLQL NLAHNAVQRL 1980
KVAIGASRKL LNETSGPEDL IQTSSTEQLR TIVRYLLDTL LSLLHSSNGH SVPAVLQSTF 2040
HAQACEELFK HLCISGTPKI RLHTGLLLVQ LCGGERWWGQ FLSNVLQELY NSEQLLIFPQ 2100
DRVFMLLSCI GQRSLSNSGV LESLLNLLDN LLSPLQPELS MHRRTEGVLD IPMISWVVML 2160
VSRLLDYVAT VEDEAAAAKK PLNGKDRERF LTGNQWSFIN NNLHTQNLNR SSKGGSSLDR 2220
LYSRKIRKQL VHHKQQLNLL KAKQKALVEQ MEKEKIQSNK GSSYKLLVEQ AKLKQATSKH 2280
FKDLIRLRRT AEWSRSNLDT EVTTTKESPE IEPLPFTLAH DRCISVVQKL VLFLLSMDFT 2340
CHADLLLFVC KVLARIANAT RPTIHLCEIV NEPQLERLLL LLVGTDFNRG DISWGGAWAQ 2400
YSLTCMLQDI LAGELLAPVA AEAMEECTVS EDVGATAGDS DDSLQQSPAQ LLETIDEPLT 2460
HEIAGTPPLS SLEKDKEIDL ELLQDLMEVD IDPLDIDLEK DPLAAKVFKP ISSTWYDYWG 2520
ADYGTYNYNP YIGGLGMPVA KPPSNTEKNG SQTVSVSVSQ ALDARLEVGL EQQAELMLKM 2580
MSTLEADSIL QALTNTSPTF SQSPTGTDDS LLGNLQPANQ NSQLMIQLSS VPMLNVCFNK 2640
LFSMLQVHHV QLESLLQLWL TLSLNSSSSG NKENGADIFL YNANRIPVIS LNQASIASFL 2700
TVLAWYPNTL LRTWCLVLHS LTLMTNMQLN SGSSSSIGIQ ETTAHLLVSD PNLIHVLVKF 2760
LSGTSPHGTN QHSPQVGPTA TQAMQEFLTR LQVHLSSTCP QIFSELLLKL IHILSTERGA 2820
FQTGQGPLDA QVKLLEFTLE QNFEVVSVST ISAVIESVTF LVHHYITCSD KVMSRSGSDS 2880
SAGARACFGG LFANLIRPGD AKAVCGEMTR DQLMFDLLKL VNILVQLPLS SNREYSARVS 2940
VTTNTTDSVS DEEKVSGGKD VNGSSASTPG SPACVADLVL ANQQIMSQIL SALGLCNSSA 3000
MAMIIGASGL HLTKHENFHG GLDAISVGDG LFTILTTLSK KASTVHMMLQ PILTYMACGY 3060
MGRQGSLATC QLSEPLLWFI LRVLDTSDAL KAFHDMGGVQ LICNNMVTST RAIVNTARSM 3120
VSTIMKFLDS GPNKAVDSTL KTRILASEPD NAEGIHNFAP LGTITSSSPT AQPAEVLLQA 3180
TPPHRRARSA AWSYIFLPEE AWCDLTIHLP SAVLLKEIHI QPHLASLATC PSSVSVEVSA 3240
DGVNMLPLST PVVTSGLTYI KIQLVKAEVA SAVCLRLHRP RDASTLGLSQ IKLLGLTAFG 3300
TTSSATVNNP FLPSEDQVSK TSIGWLRLLH HCLTHISDLE GMMASAAAPT ANLLQTCAAL 3360
LMSPYCGMHS PNIEVVLVKI GLQSTRIGLK LIDILLRNCA ASGSDPTDLN SPLLFGRLNG 3420
LSSDSTIDIL YQLGTTQDPG TKDRIQALLK WVSDSAKMAA LKRSGRMNYM CPSSSAVEYG 3480
LLMPSPSHLH CVAAILWHSY ELLVEYDLPA LLDRELFELL FNWSMSLPCN VVLKKAVDSL 3540
LCSMCHIHPN YFSLLMGWMG IIPPPVQCHH RLSMTDDSKK QDLSSSLTDD SKNAQAPLSL 3600
TESHLATLAS SSQSPEAIKQ LLDSGLPSLL VRSLASFCFS HISYSESIAQ SVDNSQDKLR 3660
RHHVPQHCNK MPITADLVAP ILRFLTEVGN SHIMKDWLGG SEVNPLWTAL LFLLCHSGST 3720
AGGHNLGAQQ SSTRSASHSS ATTTVLTTQQ RTAIENATVA FFLQCISCHP NNQKLMAQVL 3780
CELFQTAPQR GSLPTSGNIS GFVRRLFLQL MLEDEKVTMF LQSPCPLYKG RINATSHVIQ 3840
HPMFGAGHKF RTLHLPVSTT LSDVLDRVSD TPSITAKLIS EQKDDKEKKN HEEKEKVKAE 3900
NGFQDNYSVV VASGLKSQSK RAMASTPPRP PSRRGRTIPD KIGSASSSAD AASKIITVPV 3960
FHLFHRLLAG QPLPAEMTLA QLLTLLYDRK LPQGYRSIDL TVKLGSKVIT DPSLSKTDSF 4020
KRLHPEKDHG DLVGSCPEDE ALTPSDECMD GVLDESLLET CPIQSPLQVF AGMGGLALIA 4080
ERLPMLYPEV IQQVSAPVIA STTQEKPKDS DQFEWVTIEQ SGELVYEAPE TIAAEPPPVK 4140
SAVQATSPIP AHSLAAFGLF LRLPGYAEVL LKERKHAQCL LRLVLGVTDD GEGSHILQSP 4200
SANVLPTLPF HVLRSLFSAT PLTTDDGVLL RRMALEIGAL HLILVCLSAL SHHAPRVPNS 4260
SLSQTEPQVS NSHNPTSAEE QQLYWAKGTG FGTGSTASGW DVEQALTKQR LEEEHVTCLL 4320
QVLASYINPM SGAVNGEAQA SPESRAQNSS ALPSVLLELL SQSCLIPAMS SYLRNDSVLD 4380
MARHVPLYRA LLELLRAIAS CTSMVPLLLP LSTENGEEEE DEQSECQTSV GTLLAKMKTC 4440
VDTYTNRLRS KRENVKAGVK PDAPDQEPEG LALLVPDIQR TAEIVHAATA NLRQANQEKK 4500
LGEYSKKVVM KPKPLSVLKS LEEKYVAVMK KLQFDTFEMV SEDDDGKLGF KVNYHYMSQV 4560
KNANDANSAA RARRLAQEAV TLSTSLPLSS SSSVFVRCDE ERLDIMKVLI TGPADTPYAN 4620
GCFEFDVYFP QDYPSSPPLV NLETTGGHSV RFNPNLYNDG KVCLSILNTW HGRPEEKWNP 4680
QTSSFLQVLV SVQSLILVAE PYFNEPGYER SRGTPSGTQS SREYDGNIRQ ATVKWAMLEQ 4740
IRNPSPCFKE VIHKHFYLKR IELMAQCEEW IADIQQYSSD KRVGRTMSHH AAALKRHTAQ 4800
LREELLKLPC PEGLDPDIED ASPVCRATAG AEDTLTHDHV NPSSSKDLPS DFQL 4854 
Gene Ontology
 GO:0005768; C:endosome; IEA:Compara.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005815; C:microtubule organizing center; IEA:Compara.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0000922; C:spindle pole; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:Compara.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
 GO:0060711; P:labyrinthine layer development; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
 GO:0032465; P:regulation of cytokinesis; IEA:Compara.
 GO:0060712; P:spongiotrophoblast layer development; IMP:MGI. 
Interpro
 IPR001370; BIR.
 IPR022103; DUF3643.
 IPR000608; UBQ-conjugat_E2.
 IPR016135; UBQ-conjugating_enzyme/RWD.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF00653; BIR
 PF12356; DUF3643
 PF00179; UQ_con 
SMART
 SM00238; BIR 
PROSITE
 PS50143; BIR_REPEAT_2
 PS50127; UBIQUITIN_CONJUGAT_2 
PRINTS