UniProt Accession

 SEC65_YEAST; P29478; D6W0H9 

Genbank Protein ID

 X65783; Z49210; AY693145; BK006946 

Genbank Nucleotide ID

 CAA46666.1; CAA89113.1; AAT93164.1; DAA09793.1 

Protein Name

 Signal recognition particle subunit SEC65 

Protein Synonyms/Alias

  

Gene Name

 SEC65 

Gene Synonyms/Alias

 YML105C; YM8339.14C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
68	NNNSSNEKEQLSFIN	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SEC65 is required for SRP integrity. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Reference proteome; Ribonucleoprotein; Signal recognition particle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 273 AA 

Protein Sequence

Gene Ontology

 GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IDA:SGD.
 GO:0008312; F:7S RNA binding; IDA:SGD.
 GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IMP:SGD. 

Interpro

 IPR002778; Signal_recog_particle_SRP19.
 IPR022938; SRP19_arc-type. 

Pfam

 PF01922; SRP19 

SMART

  

PROSITE

  

PRINTS