CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000602
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein ZFPM1 
Protein Synonyms/Alias
 Friend of GATA protein 1; FOG-1; Friend of GATA 1; Zinc finger protein multitype 1 
Gene Name
 Zfpm1 
Gene Synonyms/Alias
 Fog; Fog1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
469PAAPRTIKVEAAEEPsumoylation[1]
507SPNPVRVKTELSSPTsumoylation[1]
Reference
 [1] Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP).
 Snow JW, Kim J, Currie CR, Xu J, Orkin SH.
 J Biol Chem. 2010 Sep 3;285(36):28064-75. [PMID: 20587419] 
Functional Description
 Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2. 
Sequence Annotation
 ZN_FING 255 278 C2HC-type 1.
 ZN_FING 303 327 C2H2-type 1.
 ZN_FING 333 355 C2H2-type 2.
 ZN_FING 361 384 C2H2-type 3.
 ZN_FING 590 613 C2HC-type 2.
 ZN_FING 696 719 C2HC-type 3.
 ZN_FING 836 859 C2HC-type 4.
 ZN_FING 868 891 C2H2-type 4.
 ZN_FING 963 986 C2HC-type 5.
 REGION 343 354 Interaction with TACC3.
 REGION 811 817 Interaction with CTBP2.
 MOD_RES 497 497 Phosphoserine.
 MOD_RES 500 500 Phosphoserine.
 MOD_RES 651 651 Phosphoserine.
 MOD_RES 666 666 Phosphothreonine.
 MOD_RES 803 803 Phosphoserine (By similarity).
 MOD_RES 925 925 Phosphoserine.
 MOD_RES 927 927 Phosphoserine.  
Keyword
 3D-structure; Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 995 AA 
Protein Sequence
MSRRKQSNPR QIKRSLRDME AGEEAKAMDS SPKEQEAPDP EAPAIEEPPS PPREDVSPPA 60
VPAPPESPED PEDMEGQELE MRPQDEEKEE KEEEAAMASP WSGPEELELA LQDGQRCVRA 120
RLSLTEGLSW GPFYGSIQTR ALSPEREEPG PAVTLMVDES CWLRMLPQVL TEEAANSEIY 180
RKDDALWCRV TKVVPSGGLL YVRLVTEPHG APRHPVQEPV EPGGLAPVHT DIQLLPQQAG 240
MASILATAVI NKDVFPCKDC GIWYRSERNL QAHLLYYCAS RQRAGSPVSA TEEKPKETYP 300
NERVCPFPQC RKSCPSASSL EIHMRSHSGE RPFVCLICLS AFTTKANCER HLKVHTDTLS 360
GVCHNCGFIS TTRDILYSHL VTNHMVCQPG SKGEIYSPGA GHPAAKLPPD SLAGFQQHSL 420
MHSPLVPADK APTPSSGLDS KAEVTNGETR VPPQNGGSSE SPAAPRTIKV EAAEEPEATR 480
ASGPGEPGPQ APSRTPSPHS PNPVRVKTEL SSPTPGSSPG PGELTMAGTL FLPQYVFSPD 540
AGTTTVPTAP QASEILAKMS ELVHNRLQQG AGSSGAAGTP TGLFSGTKGA TCFECEITFN 600
NINNFYVHKR LYCSGRRAPE DPPTVRRPKA ATGPARAPAG AAAEPDPSRS SPGPGPREEE 660
ASGTTTPEAE AAGRGSEGSQ SPGSSVDDAE DDPSRTLCEA CNIRFSRHET YTVHKRYYCA 720
SRHDPPPRRP PAPTTAPGPA APALTAPPVR TRRRRKLYEL PAAGAPPPAA GPAPVPVVPS 780
PTAELPSSPR PGSASAGPAP ALSPSPVPDG PIDLSKRPRR QSPDAPTALP ALADYHECTA 840
CRVSFHSLEA YLAHKKYSCP AAPLRTTALC PYCPPNGRVR GDLVEHLRQA HGLQVAKPAA 900
SPGAEPRTPA ERAPRDSPDG RAPRSPSPAP ENTPSDPADQ GARTPSKGPP APAPAPGGGG 960
GHRYCRLCNI RFSSLSTFIA HKKYYCSSHA AEHVK 995 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0001102; F:RNA polymerase II activating transcription factor binding; IDA:MGI.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; TAS:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060413; P:atrial septum morphogenesis; IMP:BHF-UCL.
 GO:0003181; P:atrioventricular valve morphogenesis; IMP:BHF-UCL.
 GO:0055008; P:cardiac muscle tissue morphogenesis; IMP:BHF-UCL.
 GO:0060318; P:definitive erythrocyte differentiation; IMP:MGI.
 GO:0030851; P:granulocyte differentiation; IMP:MGI.
 GO:0035855; P:megakaryocyte development; IMP:MGI.
 GO:0003192; P:mitral valve formation; IMP:BHF-UCL.
 GO:0045599; P:negative regulation of fat cell differentiation; IMP:UniProtKB.
 GO:0045403; P:negative regulation of interleukin-4 biosynthetic process; IEA:Compara.
 GO:0060377; P:negative regulation of mast cell differentiation; IDA:BHF-UCL.
 GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
 GO:0030220; P:platelet formation; IEA:Compara.
 GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Compara.
 GO:0060319; P:primitive erythrocyte differentiation; IMP:MGI.
 GO:0032642; P:regulation of chemokine production; IMP:MGI.
 GO:0010724; P:regulation of definitive erythrocyte differentiation; IEA:Compara.
 GO:0071733; P:transcriptional activation by promoter-enhancer looping; IDA:BHF-UCL.
 GO:0003195; P:tricuspid valve formation; IMP:BHF-UCL.
 GO:0060412; P:ventricular septum morphogenesis; IMP:BHF-UCL. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS