CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039598
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Diablo homolog, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 DIABLO 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50QYTSLLGKMNSEEEDubiquitination[1, 2, 3]
73ARAEMTSKHQEYLKLubiquitination[2, 3, 4]
118RNHIQLVKLQVEEVHubiquitination[1, 3, 4, 5]
Reference
 [1] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 129 AA 
Protein Sequence
MRRAVSLVTD STSTFLSQTT YALIEAITEY TKAVYTLTSL YRQYTSLLGK MNSEEEDEVW 60
QVIIGARAEM TSKHQEYLKL ETTWMTAVGL SEMAAEAAYQ TGADQASITA RNHIQLVKLQ 120
VEEVHQLSR 129 
Gene Ontology
 GO:0035631; C:CD40 receptor complex; IEA:Compara.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:InterPro.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Compara. 
Interpro
 IPR015142; Smac_DIABLO.
 IPR009062; Smac_DIABLO-like. 
Pfam
 PF09057; Smac_DIABLO 
SMART
  
PROSITE
  
PRINTS