UniProt Accession

 FSH1_YEAST; P38777; D3DKZ7 

Genbank Protein ID

 U00062; AY558283; BK006934 

Genbank Nucleotide ID

 AAB68901.1; AAS56609.1; DAA06741.1 

Protein Name

 Family of serine hydrolases 1 

Protein Synonyms/Alias

  

Gene Name

 FSH1 

Gene Synonyms/Alias

 YHR049W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
24	NGKVFSEKSSGIRKL	acetylation	[1]
122	LSSIITNKISELVPD	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Serine hydrolase of unknown specificity. 

Sequence Annotation

 ACT_SITE 110 110 Charge relay system (Probable).
 ACT_SITE 183 183 Charge relay system (Probable).
 ACT_SITE 218 218 Charge relay system (Probable).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Reference proteome; Serine esterase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 243 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW.
 GO:0016787; F:hydrolase activity; ISS:SGD. 

Interpro

 IPR005645; Serine_hydrolase_FSH. 

Pfam

 PF03959; FSH1 

SMART

  

PROSITE

  

PRINTS