CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018505
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Polyphosphoinositide phosphatase 
Protein Synonyms/Alias
 Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; SAC domain-containing protein 3 
Gene Name
 Fig4 
Gene Synonyms/Alias
 Kiaa0274; Sac3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
559HRVKTYRKIAPWTQHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. 
Sequence Annotation
 DOMAIN 154 547 SAC.  
Keyword
 Complete proteome; Endosome; Hydrolase; Membrane; Neurodegeneration; Neuropathy; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 907 AA 
Protein Sequence
MPTAAAPIIS SVQKLVLYET RARYFLVGSN HAETKYRVLK IDRTEPKDLV VIDDRHVYTQ 60
QEVRELLGRL DLGNRTKMSQ KGSSGLFRAV SAFGVVGFVR FLEGYYIVLI TKRRKMADIG 120
GHAIYKIEDT SMIYIPNDSV RISHPDEARY LRIFQNVDLS SNFYFSYSYD LSHSLQYNLT 180
VLRMPLEMLK SETSKACQES FDIFEDEGLI TQGGSGVFGI SSEPYMKYVW NGELLDIIKN 240
TVHRDWLLYI IHGFCGQSKL LIYGRPVYVT LIARRSSRFA GTRFLKRGAN CEGDVANEVE 300
TEQILCDASV MSFTAGSYSS YVQVRGSVPL FWSQDISTMM PKPPITLDQA DPFAHVAALH 360
FDQMLQRFGS PIIILNLVKE REKRKHERIL SEELVAAVTY LNQFLPPEHT IVYIPWDMAK 420
YTKSKLCNVL DRLNVIAESV VKKTGFFVNR PDSYCSILRP DEKWNELGGH VIPTGRLQTG 480
ILRTNCVDCL DRTNTAQFMV GKCALAYQLY SLGLIDKPNL QFDTDAVRLF EELYEDHGDT 540
LSLQYGGSQL VHRVKTYRKI APWTQHSKDI MQTLSRYYSN AFSDADRQDS INLFLGVFHP 600
TEGKPHLWEL PTDFYLHHKN TMSLLPPRRS YTYWWTPEVV KHLPLPYDEV ICAANLKKLM 660
VKKFHRWEEE IDIHNEFFRP YELSSFDDTF CLAMTSSARD FMPKTVGIDP SPFTVRKPDE 720
TGKSVLGNKN TREEAVLQRK TAASAPPPPS EEAVSSSSED DSGTDREDEG SISQRSTPVK 780
MTDTGDSAKA TENVVQPMKE VYGVSLSSSL SEEDHSIYAR FVQLGQSQHK QDRGNQQLCS 840
RCSDGVIKLT PISAFSQDNI YEVQPPRVDR KSTEIFQAHI QASQGIMQPL GKEDTAMYRE 900
YIRNRYL 907 
Gene Ontology
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0034593; F:phosphatidylinositol bisphosphate phosphatase activity; IEA:Compara.
 GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IEA:Compara.
 GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IEA:Compara.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0032288; P:myelin assembly; IGI:MGI.
 GO:0031642; P:negative regulation of myelination; IMP:MGI.
 GO:0048666; P:neuron development; IMP:MGI.
 GO:0046488; P:phosphatidylinositol metabolic process; IMP:MGI.
 GO:0043473; P:pigmentation; IMP:MGI.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0007033; P:vacuole organization; IMP:MGI. 
Interpro
 IPR002013; Syja_N. 
Pfam
 PF02383; Syja_N 
SMART
  
PROSITE
 PS50275; SAC 
PRINTS