| Tag | Content |
|---|
| CPLM ID | CPLM-012845 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ral GTPase-activating protein subunit alpha-2 |
Protein Synonyms/Alias | 250 kDa substrate of Akt; AS250; p220 |
Gene Name | RALGAPA2 |
Gene Synonyms/Alias | C20orf74; KIAA1272 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 425 | CEIAVTRKVVQVYRK | ubiquitination | [1] | | 1736 | SDDSLTKKLRHLGND | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB (By similarity). |
Sequence Annotation | DOMAIN 1635 1843 Rap-GAP.
MOD_RES 373 373 Phosphoserine (By similarity).
MOD_RES 376 376 Phosphoserine (By similarity).
MOD_RES 379 379 Phosphoserine (By similarity).
MOD_RES 486 486 Phosphoserine; by PKB.
MOD_RES 696 696 Phosphoserine; by PKB.
MOD_RES 715 715 Phosphothreonine; by PKB.
MOD_RES 820 820 Phosphoserine.
MOD_RES 821 821 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1873 AA |
Protein Sequence | MFSRRSHGDV KKSTQKVLDP KKDVLTRLKH LRALLDNVDA NDLKQFFETN YSQIYFIFYE 60
NFIALENSLK LKGNNKSQRE ELDSILFLFE KILQFLPERI FFRWHYQSIG STLKKLLHTG 120
NSIKIRCEGI RLFLLWLQAL QTNCAEEQVL IFACLVPGFP AVMSSRGPCT LETLINPSPS 180
VADVKIYPEE ITPLLPAISG EKIAEDQTCF FLQILLKYMV IQAASLEWKN KENQDTGFKF 240
LFTLFRKYYL PHLFPSFTKL TNIYKPVLDI PHLRPKPVYI TTTRDNENIY STKIPYMAAR 300
VVFIKWIVTF FLEKKYLTAT QNTKNGVDVL PKIIQTVGGG AVQERAPELD GGGPTEQDKS 360
HSNSSTLSDR RLSNSSLCSI EEEHRMVYEM VQRILLSTRG YVNFVNEVFH QAFLLPSCEI 420
AVTRKVVQVY RKWILQDKPV FMEEPDRKDV AQEDAEKLGF SETDSKEASS ESSGHKRSSS 480
WGRTYSFTSA MSRGCVTEEE NTNVKAGVQA LLQVFLTNSA NIFLLEPCAE VPVLLKEQVD 540
ACKAVLIIFR RMIMELTMNK KTWEQMLQIL LRITEAVMQK PKDKQIKDLF AQSLAGLLFR 600
TLMVAWIRAN LCVYISRELW DDFLGVLSSL TEWEELINEW ANIMDSLTAV LARTVYGVEM 660
TNLPLDKLSE QKEKKQRGKG CVLDPQKGTT VGRSFSLSWR SHPDVTEPMR FRSATTSGAP 720
GVEKARNIVR QKATEVEECQ QSENAPAAGS GHLTVGQQQQ VLRSSSTSDI PEPLCSDSSQ 780
GQKAENTQNS SSSEPQPIQE NKGHVKREHE GITILVRRSS SPAELDLKDD LQQTQGKCRE 840
RQKSESTNSD TTLGCTNEAE LSMGPWQTCE EDPELNTPTD VVADADARHW LQLSPTDASN 900
LTDSSECLTD DCSIIAGGSL TGWHPDSAAV LWRRVLGILG DVNNIQSPKI HARVFCYLYE 960
LWYKLAKIRD NLAISLDNQS SPSPPVLIPP LRMFASWLFK AATLPNEYKE GKLQAYRLIC 1020
AMMTRRQDVL PNSDFLVHFY LVMHLGLTSE DQDILNTIIR HCPPRFFSLG FPGFSMLVGD 1080
FITAAARVLS TDILTAPRSE AVTVLGSLVC FPNTYQEIPL LQSVPEVNEA ITGTEDVKHY 1140
LINILLKNAT EEPNEYARCI AVCSLGVWIC EELAQCTSHP QVKEAINVIG VTLKFPNKIV 1200
AQVACDVLQL LVSYWEKLQM FETSLPRKMA EILVATVAFL LPSAEYSSVE TDKKFIVSLL 1260
LCLLDWCMAL PVSVLLHPVS TAVLEEQHSA RAPLLDYIYR VLHCCVCGSS TYTQQSHYIL 1320
TLADLSSTDY DPFLPLANVK SSEPVQYHSS AELGNLLTVE EEKKRRSLEL IPLTARMVMA 1380
HLVNHLGHYP LSGGPAILHS LVSENHDNAH VEGSELSFEV FRSPNLQLFV FNDSTLISYL 1440
QTPTEGPVGG SPVGSLSDVR VIVRDISGKY SWDGKVLYGP LEGCLAPNGR NPSFLISSWH 1500
RDTFGPQKDS SQVEEGDDVL DKLLENIGHT SPECLLPSQL NLNEPSLTPC GMNYDQEKEI 1560
IEVILRQNAQ EDEYIQSHNF DSAMKVTSQG QPSPVEPRGP FYFCRLLLDD LGMNSWDRRK 1620
NFHLLKKNSK LLRELKNLDS RQCRETHKIA VFYIAEGQED KCSILSNERG SQAYEDFVAG 1680
LGWEVDLSTH CGFMGGLQRN GSTGQTAPYY ATSTVEVIFH VSTRMPSDSD DSLTKKLRHL 1740
GNDEVHIVWS EHSRDYRRGI IPTAFGDVSI IIYPMKNHMF FIAITKKPEV PFFGPLFDGA 1800
IVSGKLLPSL VCATCINASR AVKCLIPLYQ SFYEERALYL EAIIQNHREV MTFEDFAAQV 1860
FSPSPSYSLS GTD 1873 |
Gene Ontology | GO:0005829; C:cytosol; IBA:RefGenome. GO:0005634; C:nucleus; IBA:RefGenome. GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB. GO:0017123; F:Ral GTPase activator activity; ISS:UniProtKB. GO:0032859; P:activation of Ral GTPase activity; ISS:UniProtKB. GO:0016044; P:cellular membrane organization; TAS:Reactome. GO:0032484; P:Ral protein signal transduction; IEA:Compara. GO:0060178; P:regulation of exocyst localization; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |