CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027872
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Canalicular multispecific organic anion transporter cMOAT 
Protein Synonyms/Alias
  
Gene Name
 Abcc2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
276GPSHGLTKKQSQSQDubiquitination[1]
291VLVLEDAKKKKKKSEubiquitination[1]
726FGSEYDEKKYQRVIEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Nucleotide-binding; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1543 AA 
Protein Sequence
MDEFCNSTFW NLSLLKSPEA DLPLCFEQTV LVWIPLGFLW FWAPWQLYRI YRSRTKRFAI 60
TKFYLAKQVF VVCLLILAAI DLSLALTEDT GQATIPPVKY TNPILYLCTW LLVLVIQHCR 120
QCCIQKNSWF LSMFWILSLL CGIFQFQTLI RALLQDSKSN MAYSCLFFVS YGFQIVILIL 180
SAFSESSDST HAPSATASFL SSVTFSWYDS TVLKGYKHPL TIEDVWDIEE NLKAKSLTSK 240
FKTIMTKDLQ KARQALQRRL KKSQQSPEGP SHGLTKKQSQ SQDVLVLEDA KKKKKKSEAT 300
KDFPKSWLVK ALFKTFYVVI LKSFILKLAH DILLFLNPQL LKFLIGFVKD PDSYPWVGYI 360
YAILMFSVTL IQSFFLQCYF QFCFVLGMTV RTTIIASVYK EALTLSNLAR RQYTIGETVN 420
LMSVDSQKLM DVTNYIHLRW SSVLQIALSI FFLWRELGPS ILAGVGLMVL LVPVNGVLAT 480
KIRKIQVQNM KNKDKRLKIM NEILSGIKIL KYFAWEPSFK EQVNSIRKKE LRNLLRFSQL 540
QTILIFILHL TPTLVSVITF SVYVLVDSQN VLNAEKAFTS ITLFNILRFP LAMLPMVISS 600
VIQASVSVDR LEQYLGSDDL DLSAIRHVCH FDKAVQFSEA SFTWDRDLEA TIQDVNLDIK 660
PGQLVAVVGT VGSGKSSLIS AMLGEMENVH GHITIKGSIA YVPQQSWIQN GTIKDNILFG 720
SEYDEKKYQR VIEACALLPD LEMLPGGDMA EIGEKGINLS GGQKHRVSLA RATYQDADIY 780
ILDDPLSAVD THVGKHIFNK VVGPNGLLSG KTRILVTHGI HFLPQVDEIV VLGKGTILEK 840
GSYSDLMDKK GVFAKNWKTF MKHSGPEGEA TVDNDSEEED GDCGLIPTVE EIPDDAASLT 900
MRRENSLRRT LSRSSRSGSR RGKSLKSSLK IKSVNALNKK EEVVKGQKLI KKEFVETGKV 960
KFSIYLKYLQ AVGWWSLLFI VIFYVLNYVA FIGTNLWLSA WTSDSEKQNG TDNSPSQRDM 1020
RIGVFGALGI AQGIFLLSSS LWSIYACRNA SKTLHRQLLT NILRAPMSFF DTTPTGRIVN 1080
RFAGDISTVV DTLPQTLRSW LLCFFGIVST LVMICMATPI FIIIIIPLSI LYVSVQVFYV 1140
ATSRQLRRLD SVTKSPIYSH FSETVSGLPV IRAFEHQQRF LANSEKQIDT NQKCVFSWIT 1200
SNRWLAIRLE LVGNLIVFCS ALLLVIYKNS LTGDTVGFVL SNALNITQTL NWLVRMTSEV 1260
ETNIVAVERI NEYINVDNEA PWVTDKKPPA DWPKKGEIQF NNYQVRYRPE LDLVLKGITC 1320
NIKSTEKVGV VGRTGAGKSS LTNCLFRILE SAGGQIIIDG IDIASIGLHD LRGRLTIIPQ 1380
DPILFSGNLR MNLDPFNKYS DEEIWRALEL AHLKSFVAGL QLGLLHEVTE GGDNLSIGQR 1440
QLLCLGRAVL RKSKILVLDE ATAAVDLETD SLIQTTIRNE FSQCTVITIA HRLHTIMDSD 1500
KVMVLDSGKI VEYGSPEELL SNMGPFYLMA KEAGIESVNH TEL 1543 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IDA:MGI.
 GO:0046581; C:intercellular canaliculus; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005292; Multidrug-R_assoc.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS50893; ABC_TRANSPORTER_2 
PRINTS