| Tag | Content |
|---|
| CPLM ID | CPLM-003299 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-dependent Clp protease ATP-binding subunit ClpA |
Protein Synonyms/Alias | |
Gene Name | clpA |
Gene Synonyms/Alias | lopD; b0882; JW0866 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 333 | EFSNIFEKDRALARR | acetylation | [1] | | 439 | RIARIPEKSVSQSDR | acetylation | [1] | | 450 | QSDRDTLKNLGDRLK | acetylation | [1] | | 465 | MLVFGQDKAIEALTE | acetylation | [1] | | 486 | AGLGHEHKPVGSFLF | acetylation | [1] | | 633 | TDAMEEIKKIFTPEF | acetylation | [1] | | 693 | ARNWLAEKGYDRAMG | acetylation | [1] | | 713 | RVIQDNLKKPLANEL | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins. |
Sequence Annotation | NP_BIND 214 221 ATP (Potential).
NP_BIND 495 502 ATP (Potential).
REGION 169 417 I.
REGION 421 609 II. |
Keyword | 3D-structure; ATP-binding; Chaperone; Complete proteome; Direct protein sequencing; Nucleotide-binding; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 758 AA |
Protein Sequence | MLNQELELSL NMAFARAREH RHEFMTVEHL LLALLSNPSA REALEACSVD LVALRQELEA 60
FIEQTTPVLP ASEEERDTQP TLSFQRVLQR AVFHVQSSGR NEVTGANVLV AIFSEQESQA 120
AYLLRKHEVS RLDVVNFISH GTRKDEPTQS SDPGSQPNSE EQAGGEERME NFTTNLNQLA 180
RVGGIDPLIG REKELERAIQ VLCRRRKNNP LLVGESGVGK TAIAEGLAWR IVQGDVPEVM 240
ADCTIYSLDI GSLLAGTKYR GDFEKRFKAL LKQLEQDTNS ILFIDEIHTI IGAGAASGGQ 300
VDAANLIKPL LSSGKIRVIG STTYQEFSNI FEKDRALARR FQKIDITEPS IEETVQIING 360
LKPKYEAHHD VRYTAKAVRA AVELAVKYIN DRHLPDKAID VIDEAGARAR LMPVSKRKKT 420
VNVADIESVV ARIARIPEKS VSQSDRDTLK NLGDRLKMLV FGQDKAIEAL TEAIKMARAG 480
LGHEHKPVGS FLFAGPTGVG KTEVTVQLSK ALGIELLRFD MSEYMERHTV SRLIGAPPGY 540
VGFDQGGLLT DAVIKHPHAV LLLDEIEKAH PDVFNILLQV MDNGTLTDNN GRKADFRNVV 600
LVMTTNAGVR ETERKSIGLI HQDNSTDAME EIKKIFTPEF RNRLDNIIWF DHLSTDVIHQ 660
VVDKFIVELQ VQLDQKGVSL EVSQEARNWL AEKGYDRAMG ARPMARVIQD NLKKPLANEL 720
LFGSLVDGGQ VTVALDKEKN ELTYGFQSAQ KHKAEAAH 758 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |