CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042805
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho GTPase-activating protein 1 
Protein Synonyms/Alias
  
Gene Name
 ARHGAP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
166GIPRQVLKYDDFLKSacetylation[1]
166GIPRQVLKYDDFLKSubiquitination[2, 3, 4]
172LKYDDFLKSTQKSPAubiquitination[5]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 334 AA 
Protein Sequence
XLSELQDDLT LDDTSEALNQ LKLASIDEKN WPSDEMPDFP KSDDSKSSSP ELVTHLKWDD 60
PYYDIARHQI VEVAGDDKYG RKIIVFSACR MPPSHQLDHS KLLGYKKNIK ALYIVHPTMF 120
IKTLLILFKP LISFKFGQKI FYVNYLSELS EHVKLEQLGI PRQVLKYDDF LKSTQKSPAT 180
APKPMPPRPP LPNQQFGVSL QHLQEKNPEQ EPIPIVLRET VAYLQAHALT TEGIFRRSAN 240
TQVVREVQQK YNMGLPVDFD QYNELHLPAV ILKTFLRELP EPLLTFDLYP HVVGFLNIDE 300
SQRVPATLQV LQTLPEENYQ VLRFLTAFLV QISA 334 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR001251; CRAL-TRIO_dom.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00620; RhoGAP 
SMART
 SM00324; RhoGAP 
PROSITE
 PS50191; CRAL_TRIO
 PS50238; RHOGAP 
PRINTS