CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038669
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ephexin-1 
Protein Synonyms/Alias
  
Gene Name
 Ngef 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
399AQLELDPKCKGLPFSubiquitination[1]
428LLVQNILKRVEERSEubiquitination[1]
492SHSRWLLKQGELQQMubiquitination[1]
603LAPNRRTKFVSFTSRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 710 AA 
Protein Sequence
METKNSEDWG KPQRKSESSS RKSNHGPAEM RPALPPENRE APETGEETQN EEPRRLIPIQ 60
RHSLFNRAVR HRHKARSTSE RRASDQADLP KMGKSVNERS AFNLPQGRLP PWRTPAQRDT 120
GAQEASESSS TPGNGTTPEE CPALTDSPTT LTEALQMIHP IPADSWRNLI EQIGLLYQEY 180
RDKSTLQEIE TRRQQDAEIQ GNSDGSQVGE DAGEEEEEEE EGEEEELASP PERRALPQIC 240
LLSNPHSRFN LWQDLPEIQS SGVLDILQPE EIRLQEAMFE LVTSEASYYK SLNLLVSHFM 300
ENERLKKILH PSEAHILFSN VLDVMAVSER FLLELEHRME ENIVISDVCD IVYRYAADHF 360
SVYITYVSNQ TYQERTYKQL LQEKAAFREL IAQLELDPKC KGLPFSSFLI LPFQRITRLK 420
LLVQNILKRV EERSEREGTA LDAHKELEMV VKACNEGVRK MSRTEQMISI QKKMEFKIKS 480
VPIISHSRWL LKQGELQQMS GPKTSRTLRT KKLFREIYLF LFNDLLVICR QIPGDKYQVF 540
DSAPRGLLRV EELEDQGQTL ANVFILRLLE NADDREATYM LKASSQSEMK RWMTSLAPNR 600
RTKFVSFTSR LLDCPQVQCV HPYVAQQPDE LTLELADILN ILEKTEDGWI FGERLHDQER 660
GWFPSSMTEE ILNPKIRSQN LKECFRVHKM EDPQRSQNKD RRKLGSRNRQ 710 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0009987; P:cellular process; IDA:MGI.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001452; SH3_domain. 
Pfam
 PF00621; RhoGEF
 PF00018; SH3_1 
SMART
 SM00233; PH
 SM00325; RhoGEF
 SM00326; SH3 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50002; SH3 
PRINTS