UniProt Accession

 SNG1_HUMAN; O43759; A6NP69; A8K0E2; O43757; O43758; Q53Y02; Q96J56; Q9UGZ4 

Genbank Protein ID

 AJ002303; AJ002304; AJ002305; CR456590; BT007135; AK289507; AL022326; BC000731 

Genbank Nucleotide ID

 CAA05320.1; CAA05321.1; CAA05322.1; CAG30476.1; AAP35799.1; BAF82196.1; CAA18452.1; AAH00731.1 

Protein Name

 Synaptogyrin-1 

Protein Synonyms/Alias

  

Gene Name

 SYNGR1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	GGAYGAGKAGGAFDP	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). 

Sequence Annotation

 DOMAIN 20 173 MARVEL.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 Acetylation; Alternative splicing; Cell junction; Complete proteome; Membrane; Polymorphism; Reference proteome; Synapse; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 233 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0030672; C:synaptic vesicle membrane; IEA:Compara.
 GO:0006605; P:protein targeting; IEA:Compara.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; ISS:UniProtKB.
 GO:0048172; P:regulation of short-term neuronal synaptic plasticity; ISS:UniProtKB. 

Interpro

 IPR008253; Marvel.
 IPR021128; MARVEL-like_dom.
 IPR016579; Synaptogyrin. 

Pfam

 PF01284; MARVEL 

SMART

  

PROSITE

 PS51225; MARVEL 

PRINTS