Tag | Content |
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CPLM ID | CPLM-024759 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inosine-5'-monophosphate dehydrogenase 2 |
Protein Synonyms/Alias | IMP dehydrogenase 2; IMPD 2; IMPDH 2 |
Gene Name | Impdh2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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436 | RYFSEADKIKVAQGV | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (By similarity). |
Sequence Annotation | DOMAIN 114 173 CBS 1. DOMAIN 179 237 CBS 2. NP_BIND 274 276 NAD (By similarity). NP_BIND 324 326 NAD (By similarity). REGION 364 366 IMP binding (By similarity). REGION 387 388 IMP binding (By similarity). REGION 411 415 IMP binding (By similarity). ACT_SITE 331 331 Thioimidate intermediate (By similarity). METAL 326 326 Potassium; via carbonyl oxygen (By METAL 328 328 Potassium; via carbonyl oxygen (By METAL 331 331 Potassium; via carbonyl oxygen (By METAL 500 500 Potassium; via carbonyl oxygen; shared METAL 501 501 Potassium; via carbonyl oxygen; shared METAL 502 502 Potassium; via carbonyl oxygen; shared BINDING 329 329 IMP (By similarity). BINDING 441 441 IMP (By similarity). MOD_RES 122 122 Phosphoserine (By similarity). MOD_RES 400 400 Phosphotyrosine (By similarity). MOD_RES 416 416 Phosphoserine (By similarity). MOD_RES 511 511 N6-acetyllysine (By similarity). |
Keyword | Acetylation; CBS domain; Complete proteome; Cytoplasm; GMP biosynthesis; Metal-binding; NAD; Nucleus; Oxidoreductase; Phosphoprotein; Potassium; Purine biosynthesis; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 514 AA |
Protein Sequence | MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT 60 LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV 120 LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDRFLEEIMT 180 KREDLVVAPA GVTLKEANEI LQRSKKGKLP IVNESDELVA IIARTDLKKN RDYPLASKDT 240 KKQLLCGAAI GTHEDDKYRL DLLALAGVDV VVLDSSQGNS IFQINMIKYI KEKYPNLQVI 300 GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV SEYARRFGVP 360 VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM 420 DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR 480 AMMYSGELKF EKRTSSAQVE GGVHGLHSYE KRLF 514 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005778; C:peroxisomal membrane; IEA:Compara. GO:0003938; F:IMP dehydrogenase activity; IDA:RGD. GO:0046872; F:metal ion binding; IEA:HAMAP. GO:0000166; F:nucleotide binding; IEA:HAMAP. GO:0006177; P:GMP biosynthetic process; IEA:HAMAP. GO:0046651; P:lymphocyte proliferation; IEA:Compara. GO:0051289; P:protein homotetramerization; IDA:RGD. GO:0006164; P:purine nucleotide biosynthetic process; IDA:RGD. GO:0060041; P:retina development in camera-type eye; IEP:RGD. |
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