CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030078
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fructose-bisphosphate aldolase, class II 
Protein Synonyms/Alias
  
Gene Name
 fbaA 
Gene Synonyms/Alias
 ECDH10B_3100 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12 / DH10B) 
NCBI Taxa ID
 316385 
Lysine Modification
Position
Peptide
Type
References
9SKIFDFVKPGVITGDmalonylation[1]
9SKIFDFVKPGVITGDsuccinylation[2]
72GASFIAGKGVKSDVPsuccinylation[2]
115HTDHCAKKLLPWIDGsuccinylation[2]
231GNVHGVYKPGNVVLTsuccinylation[2]
251DSQEYVSKKHNLPHNsuccinylation[2]
319QGQLGNPKGEDQPNKsuccinylation[2]
326KGEDQPNKKYYDPRVsuccinylation[2]
348SMIARLEKAFQELNAsuccinylation[2]
Reference
 [1] The first identification of lysine malonylation substrates and its regulatory enzyme.
 Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y.
 Mol Cell Proteomics. 2011 Dec;10(12):M111.012658. [PMID: 21908771]
 [2] Identification of lysine succinylation as a new post-translational modification.
 Zhang Z, Tan M, Xie Z, Dai L, Chen Y, Zhao Y.
 Nat Chem Biol. 2011 Jan;7(1):58-63. [PMID: 21151122] 
Functional Description
  
Sequence Annotation
 REGION 266 268 Dihydroxyacetone phosphate binding (By
 REGION 287 290 Dihydroxyacetone phosphate binding (By
 ACT_SITE 110 110 Proton donor (By similarity).
 BINDING 228 228 Dihydroxyacetone phosphate; via amide  
Keyword
 Complete proteome; Lyase; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MSKIFDFVKP GVITGDDVQK VFQVAKENNF ALPAVNCVGT DSINAVLETA AKVKAPVIVQ 60
FSNGGASFIA GKGVKSDVPQ GAAILGAISG AHHVHQMAEH YGVPVILHTD HCAKKLLPWI 120
DGLLDAGEKH FAATGKPLFS SHMIDLSEES LQENIEICSK YLERMSKIGM TLEIELGCTG 180
GEEDGVDNSH MDASALYTQP EDVDYAYTEL SKISPRFTIA ASFGNVHGVY KPGNVVLTPT 240
ILRDSQEYVS KKHNLPHNSL NFVFHGGSGS TAQEIKDSVS YGVVKMNIDT DTQWATWEGV 300
LNYYKANEAY LQGQLGNPKG EDQPNKKYYD PRVWLRAGQT SMIARLEKAF QELNAIDVL 359 
Gene Ontology
 GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:InterPro. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR006411; Fruct_bisP_bact.
 IPR000771; Ketose_bisP_aldolase_II. 
Pfam
 PF01116; F_bP_aldolase 
SMART
  
PROSITE
 PS00602; ALDOLASE_CLASS_II_1
 PS00806; ALDOLASE_CLASS_II_2 
PRINTS