CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012843
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pre-rRNA-processing protein TSR1 homolog 
Protein Synonyms/Alias
  
Gene Name
 TSR1 
Gene Synonyms/Alias
 KIAA1401 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38GKGRLALKTLSKKVRubiquitination[1, 2]
219EKRFPHDKLLLLDTQubiquitination[3]
240LRQLANQKQQHLAFRubiquitination[2]
470VDEEAEAKMLEKYKQubiquitination[4]
502AARIRFQKYRGLKSFubiquitination[2]
609PGNTEPVKAKEELIFubiquitination[4]
637SQHTAADKHKLQRFLubiquitination[2]
709HPFKIFTKMAVVRYMubiquitination[3]
727REDVLWFKPVELRTKubiquitination[4]
758MKCSFDGKLKSQDTVubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Direct protein sequencing; Nucleus; Polymorphism; Reference proteome; Ribosome biogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 804 AA 
Protein Sequence
MAAHRPGPLK QQNKAHKGGR HRGRGSAQRD GKGRLALKTL SKKVRKELSR VDQRHRASQL 60
RKQKKEAVLA EKRQLGGKDG PPHQVLVVPL HSRISLPEAM QLLQDRDTGT VHLNELGNTQ 120
NFMLLCPRLK HRWFFTSARP GDLHVVLDMA KVADTILFLL DPLEGWDSTG DYCLSCLFAQ 180
GLPTYTLAVQ GISGLPLKKQ IDTRKKLSKA VEKRFPHDKL LLLDTQQEAG MLLRQLANQK 240
QQHLAFRDRR AYLFAHAVDF VPSEENNLVG TLKISGYVRG QTLNVNRLLH IVGYGDFQMK 300
QIDAPGDPFP LNPRGIKPQK DPDMAMEICA TDAVDDMEEG LKVLMKADPG RQESLQAEVI 360
PDPMEGEQTW PTEEELSEAK DFLKESSKVV KKVPKGTSSY QAEWILDGGS QSGGEGDEYE 420
YDDMEHEDFM EEESQDESSE EEEEYETMTI GESVHDDLYD KKVDEEAEAK MLEKYKQERL 480
EEMFPDEVDT PRDVAARIRF QKYRGLKSFR TSPWDPKENL PQDYARIFQF QNFTNTRKSI 540
FKEVEEKEVE GAEVGWYVTL HVSEVPVSVV ECFRQGTPLI AFSLLPHEQK MSVLNMVVRR 600
DPGNTEPVKA KEELIFHCGF RRFRASPLFS QHTAADKHKL QRFLTADMAL VATVYAPITF 660
PPASVLLFKQ KSNGMHSLIA TGHLMSVDPD RMVIKRVVLS GHPFKIFTKM AVVRYMFFNR 720
EDVLWFKPVE LRTKWGRRGH IKEPLGTHGH MKCSFDGKLK SQDTVLMNLY KRVFPKWTYD 780
PYVPEPVPWL KSEISSTVPQ GGME 804 
Gene Ontology
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0042255; P:ribosome assembly; ISS:UniProtKB. 
Interpro
 IPR012948; AARP2CN.
 IPR007034; BMS1_TSR1_C. 
Pfam
 PF08142; AARP2CN
 PF04950; DUF663 
SMART
 SM00785; AARP2CN 
PROSITE
  
PRINTS