CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041969
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide exchange factor DBS 
Protein Synonyms/Alias
 MCF.2 cell line derived transforming sequence-like, isoform CRA_a 
Gene Name
 MCF2L 
Gene Synonyms/Alias
 hCG_27883 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
209TLSDIAFKFNRDDFKubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1182 AA 
Protein Sequence
MARVESPVPA ARASLTGSCV LGQAMPLRGG AGPSPASHGP THGPSDPRTC LPGRGAGGMR 60
PHGRGALGCC GLCSFYTCHG AAGDEIMHQD IVPLCAADIQ DQLKKRFAYL SGGRGQDGSP 120
VITFPDYPAF SEIPDKEFQN VMTYLTSIPS LQDAGIGFIL VIDRRRDKWT SVKASVLRIA 180
ASFPANLQLV LVLRPTGFFQ RTLSDIAFKF NRDDFKMKVP VIMLSSVPDL HGYIDKSQLT 240
EDLGGTLDYC HSRWLCQRTA IESFALMVKQ TAQMLQSFGT ELAETELPND VQSTSSVLCA 300
HTEKKDKAKE DLRLALKEGH SVLESLRELQ AEGSEPSVNQ DQLDNQATVQ RLLAQLNETE 360
AAFDEFWAKH QQKLEQCLQL RHFEQGFREV KAILDAASQK IATFTDIGNS LAHVEHLLRD 420
LASFEEKSGV AVERARALSL DGEQLIGNKH YAVDSIRPKC QELRHLCDQF SAEIARRRGL 480
LSKSLELHRR LETSMKWCDE GIYLLASQPV DKCQSQDGAE AALQEIEKFL ETGAENKIQE 540
LNAIYKEYES ILNQDLMEHV RKVFQKQASM EEVFHRRQAS LKKLAARQTR PVQPVAPRPE 600
ALAKSPCPSP GIRRGSENSS SEGGALRRGP YRRAKSEMSE SRQGRGSAGE EEESLAILRR 660
HVMSELLDTE RAYVEELLCV LEGYAAEMDN PLMAHLLSTG LHNKKDVLFG NMEEIYHFHN 720
RIFLRELENY TDCPELVGRC FLERMEDFQI YEKYCQNKPR SESLWRQCSD CPFFQECQRK 780
LDHKLSLDSY LLKPVQRITK YQLLLKEMLK YSRNCEGAED LQEALSSILG ILKAVNDSMH 840
LIAITGYDGN LGDLGKLLMQ GSFSVWTDHK RGHTKVKELA RFKPMQRHLF LHEKAVLFCK 900
KREENGEGYE KAPSYSYKQS LNMAAVGITE NVKGDAKKFE IWYNAREEVY IVQAPTPEIK 960
AAWVNEIRKV LTSQLQACRE ASQHRALEQS QSLPLPAPTS TSPSRGNSRN IKKLEERKTD 1020
PLSLEGYVSS APLTKPPEKG KGWSKTSHSL EAPEDDGGWS SAEEQINSSD AEEDGGLGPK 1080
KLVPGKYTVV ADHEKGGPDA LRVRSGDVVE LVQEGDEGLW YVRDPTTGKE GWVPASSLSV 1140
RLGPSGSAQC LSSSESSPGS AVLSNSSSCS EGGQAPFSDL QG 1182 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR001251; CRAL-TRIO_dom.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR011511; SH3_2.
 IPR001452; SH3_domain.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00169; PH
 PF00621; RhoGEF
 PF07653; SH3_2
 PF00435; Spectrin 
SMART
 SM00233; PH
 SM00325; RhoGEF
 SM00516; SEC14
 SM00326; SH3
 SM00150; SPEC 
PROSITE
 PS50191; CRAL_TRIO
 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50002; SH3 
PRINTS