UniProt Accession

 E9PXV3_MOUSE; E9PXV3 

Genbank Protein ID

 AC102591; AC110174 

Genbank Nucleotide ID

  

Protein Name

 Calcium/calmodulin-dependent protein kinase type II subunit beta 

Protein Synonyms/Alias

  

Gene Name

 Camk2d 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
138	GIVHRDLKPENLLLA	acetylation	[1]
138	GIVHRDLKPENLLLA	ubiquitination	[2]
227	HRLYQQIKAGAYDFP	acetylation	[3]
227	HRLYQQIKAGAYDFP	ubiquitination	[2]
246	DTVTPEAKDLINKML	ubiquitination	[2]
251	EAKDLINKMLTINPA	ubiquitination	[2]
259	MLTINPAKRITASEA	ubiquitination	[2]
268	ITASEALKHPWICQR	acetylation	[4]
268	ITASEALKHPWICQR	ubiquitination	[2]
292	QETVDCLKKFNARRK	ubiquitination	[2]
301	FNARRKLKGAILTTM	ubiquitination	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 488 AA 

Protein Sequence

Gene Ontology

 GO:0043194; C:axon initial segment; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0014704; C:intercalated disc; IDA:MGI.
 GO:0031594; C:neuromuscular junction; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0030315; C:T-tubule; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
 GO:0006816; P:calcium ion transport; IDA:MGI.
 GO:0060048; P:cardiac muscle contraction; IDA:MGI.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:MGI.
 GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.
 GO:0046777; P:protein autophosphorylation; IMP:MGI.
 GO:0002028; P:regulation of sodium ion transport; IDA:MGI. 

Interpro

 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR013543; Ca/CaM-dep_prot_kinase-assoc.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF08332; CaMKII_AD
 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS