| Tag | Content |
|---|
| CPLM ID | CPLM-020147 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synaptotagmin-11 |
Protein Synonyms/Alias | Synaptotagmin XI; SytXI |
Gene Name | SYT11 |
Gene Synonyms/Alias | KIAA0080 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 54 | KQKNPPYKFIHMLKG | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). |
Sequence Annotation | DOMAIN 174 262 C2 1.
DOMAIN 304 397 C2 2.
METAL 188 188 Calcium 1 (By similarity).
METAL 188 188 Calcium 2 (By similarity).
METAL 195 195 Calcium 1 (By similarity).
METAL 249 249 Calcium 1; via carbonyl oxygen (By
METAL 250 250 Calcium 1 (By similarity).
METAL 250 250 Calcium 2 (By similarity).
METAL 250 250 Calcium 3 (By similarity).
METAL 253 253 Calcium 3 (By similarity).
METAL 256 256 Calcium 2 (By similarity).
METAL 256 256 Calcium 3 (By similarity). |
Keyword | Calcium; Cell junction; Complete proteome; Cytoplasmic vesicle; Membrane; Metal-binding; Polymorphism; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 431 AA |
Protein Sequence | MAEITNIRPS FDVSPVVAGL IGASVLVVCV SVTVFVWSCC HQQAEKKQKN PPYKFIHMLK 60
GISIYPETLS NKKKIIKVRR DKDGPGREGG RRNLLVDAAE AGLLSRDKDP RGPSSGSCID 120
QLPIKMDYGE ELRSPITSLT PGESKTTSPS SPEEDVMLGS LTFSVDYNFP KKALVVTIQE 180
AHGLPVMDDQ TQGSDPYIKM TILPDKRHRV KTRVLRKTLD PVFDETFTFY GIPYSQLQDL 240
VLHFLVLSFD RFSRDDVIGE VMVPLAGVDP STGKVQLTRD IIKRNIQKCI SRGELQVSLS 300
YQPVAQRMTV VVLKARHLPK MDITGLSGNP YVKVNVYYGR KRIAKKKTHV KKCTLNPIFN 360
ESFIYDIPTD LLPDISIEFL VIDFDRTTKN EVVGRLILGA HSVTASGAEH WREVCESPRK 420
PVAKWHSLSE Y 431 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005887; C:integral to plasma membrane; IEA:Compara. GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005215; F:transporter activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |