CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010696
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Disks large-associated protein 1 
Protein Synonyms/Alias
 DAP-1; Guanylate kinase-associated protein; rGKAP; PSD-95/SAP90-binding protein 1; SAP90/PSD-95-associated protein 1; SAPAP1 
Gene Name
 Dlgap1 
Gene Synonyms/Alias
 Gkap 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
300RAREVYQKASVNMDQubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Part of the postsynaptic scaffold in neuronal cells. 
Sequence Annotation
 REGION 665 676 Interaction with DYL2.
 REGION 687 698 Interaction with DYL2.
 MOTIF 990 992 PDZ-binding.
 MOD_RES 123 123 Phosphotyrosine (By similarity).
 MOD_RES 134 134 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine (By similarity).
 MOD_RES 362 362 Phosphoserine (By similarity).
 MOD_RES 389 389 Phosphoserine (By similarity).
 MOD_RES 412 412 Phosphoserine (By similarity).
 MOD_RES 421 421 Phosphoserine (By similarity).
 MOD_RES 436 436 Phosphothreonine (By similarity).
 MOD_RES 437 437 Phosphoserine (By similarity).
 MOD_RES 446 446 Phosphoserine (By similarity).
 MOD_RES 499 499 Phosphoserine (By similarity).
 MOD_RES 509 509 Phosphoserine (By similarity).
 MOD_RES 516 516 Phosphoserine (By similarity).
 MOD_RES 947 947 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 992 AA 
Protein Sequence
MKGLSGSRSH HHGITCESAC DSLSHHSDHK PYLLSPVDHH PADHPYYTQR NSFQAECVGP 60
FSDPLASSTF PRRHYTSQQE LKDESALVPR TLATKANRLP TNLLDQFERQ LPLSRDGYHT 120
LQYKRTAVEH RSDSPGRIRH LVHSVQKLFT KSHSLEGASK GGVNGGKASP DGSQTVRYGK 180
RSKSKERRSE PKARSNASNA SPTSPSWWSS DDNLDGDMCL YHTPSGVMTM GRCPDRSVSQ 240
YFMGAYNTIS EQAVKASRSN NDVKCSTCAN LPVTLDAPLL KKSAWSSTLT VSRAREVYQK 300
ASVNMDQAVV KSEACQQERS CQYLQVPQDE WTGYTPRGKD DEIPCRRMRS GSYIKAMGDE 360
DSGDSDTSPK PSPKVAARRE SYLKATQPSL TELTTLKISN EHSPKLQIRS HSYLRAVSEV 420
SINRSLDSLD PAGLLTSPKF RSRNESYMRA MSTISQVSEM EVNGQFESVC ESVFSELESQ 480
AVEALDLPMP GCFRMRSHSY VRAIEKGCSQ DDECVSLRSS SPPRTTTTVR TIQSSTGVIK 540
LSSAVEVSSC ITTYKKTPPP VPPRTTTKPF ISITAQSSTE SAQDAYMDGQ GQRGDMISQS 600
GLSNSTESLD SMKALTAAIE AANAQIHGPA SQHMGSNAAA VTTTTTIATV TTEDRKKDFK 660
KNRCLSIGIQ VDDAEESEKM AESKTSSKFQ SVGVQVEEEK CFRRFTRSNS VTTAVQADLD 720
FHDNLENSLE SIEDNSCPGP MARQFSRDAS TSTVSIQGSG NHYHACAADD DFDTDFDPSI 780
LPPPDPWIDS ITEDPLEAVQ RSVCHRDGHW FLKLLQAERD RMEGWCKQME REERENNLPE 840
DILGKIRTAV GSAQLLMAQK FYQFRELCEE NLNPNAHPRP TSQDLAGFWD MLQLSIENIS 900
MKFDELHQLK ANNWKQMDPL DKKERRAPPP VPKKPAKGPA PLIRERSLES SQRQEARKRL 960
MAAKRAASVR QNSATESAES IEIYIPEAQT RL 992 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IDA:RGD.
 GO:0019904; F:protein domain specific binding; IDA:RGD.
 GO:0070842; P:aggresome assembly; IMP:BHF-UCL.
 GO:0007267; P:cell-cell signaling; IEA:InterPro.
 GO:0035418; P:protein localization to synapse; IMP:BHF-UCL.
 GO:0061136; P:regulation of proteasomal protein catabolic process; IMP:BHF-UCL. 
Interpro
 IPR005026; GKAP. 
Pfam
 PF03359; GKAP 
SMART
  
PROSITE
  
PRINTS