UniProt Accession

 APOC1_HUMAN; P02654; Q6IB97 

Genbank Protein ID

 X00570; M20843; AF050154; AY422954; BT007142; CR456907; AM392727; BC009698; BC055093; M20902; M27359 

Genbank Nucleotide ID

 CAA25235.1; AAA51763.1; AAD02506.1; AAQ91813.1; AAP35806.1; CAG33188.1; CAL37605.1; AAH09698.1; AAH55093.1; AAA88018.1; AAA51762.1 

Protein Name

 Apolipoprotein C-I 

Protein Synonyms/Alias

 Apo-CIB; ApoC-IB; Apolipoprotein C1; Truncated apolipoprotein C-I; Apo-CIB'; ApoC-IB' 

Gene Name

 APOC1 

Gene Synonyms/Alias

 APOC1B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	KQSELSAKMREWFSE	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Lipid transport; Polymorphism; Reference proteome; Secreted; Signal; Transport; VLDL. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 83 AA 

Protein Sequence

Gene Ontology

 GO:0042627; C:chylomicron; TAS:BHF-UCL.
 GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
 GO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL.
 GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
 GO:0005504; F:fatty acid binding; IDA:BHF-UCL.
 GO:0031210; F:phosphatidylcholine binding; TAS:BHF-UCL.
 GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; TAS:BHF-UCL.
 GO:0004859; F:phospholipase inhibitor activity; IDA:BHF-UCL.
 GO:0033344; P:cholesterol efflux; IDA:BHF-UCL.
 GO:0034382; P:chylomicron remnant clearance; IDA:BHF-UCL.
 GO:0034375; P:high-density lipoprotein particle remodeling; TAS:BHF-UCL.
 GO:0006629; P:lipid metabolic process; TAS:ProtInc.
 GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
 GO:0032375; P:negative regulation of cholesterol transport; IDA:BHF-UCL.
 GO:0045717; P:negative regulation of fatty acid biosynthetic process; IDA:BHF-UCL.
 GO:0051005; P:negative regulation of lipoprotein lipase activity; IDA:BHF-UCL.
 GO:0010900; P:negative regulation of phosphatidylcholine catabolic process; IDA:BHF-UCL.
 GO:0048261; P:negative regulation of receptor-mediated endocytosis; IDA:BHF-UCL.
 GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IDA:BHF-UCL.
 GO:0033700; P:phospholipid efflux; IDA:BHF-UCL.
 GO:0010873; P:positive regulation of cholesterol esterification; TAS:BHF-UCL.
 GO:0034379; P:very-low-density lipoprotein particle assembly; TAS:BHF-UCL.
 GO:0034447; P:very-low-density lipoprotein particle clearance; IGI:BHF-UCL. 

Interpro

 IPR006781; ApoC-I. 

Pfam

 PF04691; ApoC-I 

SMART

  

PROSITE

  

PRINTS