UniProt Accession

 NDUS7_HUMAN; O75251; Q2T9H7; Q9BV17 

Genbank Protein ID

 AC005329; BC001715; BC005954; BC111517 

Genbank Nucleotide ID

 AAC27669.1; AAH01715.2; AAH05954.1; AAI11518.1 

Protein Name

 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial 

Protein Synonyms/Alias

 Complex I-20kD; CI-20kD; NADH-ubiquinone oxidoreductase 20 kDa subunit; PSST subunit 

Gene Name

 NDUFS7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	STQPALPKARAVAPK	ubiquitination	[1]
66	RGEYVVAKLDDLVNW	ubiquitination	[1]
129	VAGTLTNKMAPALRK	ubiquitination	[1]
136	KMAPALRKVYDQMPE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 

Sequence Annotation

 METAL 88 88 Iron-sulfur (4Fe-4S) (Potential).
 METAL 89 89 Iron-sulfur (4Fe-4S) (Potential).
 METAL 153 153 Iron-sulfur (4Fe-4S) (Potential).
 METAL 183 183 Iron-sulfur (4Fe-4S) (Potential).  

Keyword

 4Fe-4S; Complete proteome; Disease mutation; Electron transport; Iron; Iron-sulfur; Leigh syndrome; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Polymorphism; Reference proteome; Respiratory chain; Transit peptide; Transport; Ubiquinone. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 213 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0097060; C:synaptic membrane; IEA:Compara.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
 GO:0048038; F:quinone binding; IEA:InterPro.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
 GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR006137; NADH_UbQ_OxRdtase-like_20kDa.
 IPR006138; NADH_UQ_OxRdtase_20Kd_su.
 IPR014406; NiFe-hyd_3_ssu/Q_oxred_NuoB. 

Pfam

 PF01058; Oxidored_q6 

SMART

  

PROSITE

 PS01150; COMPLEX1_20K 

PRINTS