UniProt Accession

 FNTA_HUMAN; P49354; A6NJW0; Q53XJ9; Q9UDC1 

Genbank Protein ID

 L10413; L00634; AC110275; BT009854; AK292121; AC113191; BC017029; BC084566; AL698961 

Genbank Nucleotide ID

 AAA86285.1; AAA35853.1; AAP88856.1; BAF84810.1; AAH17029.2; AAH84566.1 

Protein Name

 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 

Protein Synonyms/Alias

 CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha 

Gene Name

 FNTA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
95	VQIIYSDKFRDVYDY	ubiquitination	[1]
142	HFRRVLLKSLQKDLH	ubiquitination	[2]
228	QYVDQLLKEDVRNNS	ubiquitination	[1]
366	IGRSLQSKHSTENDS	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). 

Sequence Annotation

 REPEAT 112 146 PFTA 1.
 REPEAT 147 180 PFTA 2.
 REPEAT 181 215 PFTA 3.
 REPEAT 216 249 PFTA 4.
 REPEAT 255 289 PFTA 5.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 373 373 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Prenyltransferase; Reference proteome; Repeat; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 379 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005875; C:microtubule associated complex; IDA:BHF-UCL.
 GO:0043014; F:alpha-tubulin binding; IDA:BHF-UCL.
 GO:0004662; F:CAAX-protein geranylgeranyltransferase activity; IEA:EC.
 GO:0008017; F:microtubule binding; IDA:BHF-UCL.
 GO:0004660; F:protein farnesyltransferase activity; TAS:ProtInc.
 GO:0004661; F:protein geranylgeranyltransferase activity; TAS:ProtInc.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0090045; P:positive regulation of deacetylase activity; IDA:BHF-UCL.
 GO:0090044; P:positive regulation of tubulin deacetylation; IDA:BHF-UCL.
 GO:0018343; P:protein farnesylation; IDA:BHF-UCL.
 GO:0018344; P:protein geranylgeranylation; TAS:ProtInc.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc. 

Interpro

 IPR002088; Prenyl_trans_a. 

Pfam

 PF01239; PPTA 

SMART

  

PROSITE

 PS51147; PFTA 

PRINTS