CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008417
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal transducer and activator of transcription 5B 
Protein Synonyms/Alias
  
Gene Name
 STAT5B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
71LVQELQKKAEHQVGEubiquitination[1]
140LADAMSQKHLQINQTubiquitination[1]
694PCESATAKAVDGYVKubiquitination[1]
701KAVDGYVKPQIKQVVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. 
Sequence Annotation
 DOMAIN 589 686 SH2.
 REGION 232 321 Required for interaction with NMI.
 MOD_RES 128 128 Phosphoserine.
 MOD_RES 193 193 Phosphoserine.
 MOD_RES 699 699 Phosphotyrosine; by HCK, JAK and PTK6.  
Keyword
 Activator; Complete proteome; Cytoplasm; Disease mutation; DNA-binding; Dwarfism; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 787 AA 
Protein Sequence
MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN PQENIKATQL 60
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV 120
REANNGSSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL 180
RIQAQFGPLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL 240
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 300
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 360
NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS 420
LKRIKRSDRR GAESVTEEKF TILFESQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA 480
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN 540
SSSHLEDYSG LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK 600
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL 660
GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV KPQIKQVVPE FVNASADAGG 720
GSATYMDQAP SPAVCPQAHY NMYPQNPDSV LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ 780
WIPHAQS 787 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0006103; P:2-oxoglutarate metabolic process; ISS:BHF-UCL.
 GO:0006953; P:acute-phase response; IEA:Compara.
 GO:0000255; P:allantoin metabolic process; ISS:BHF-UCL.
 GO:0006101; P:citrate metabolic process; ISS:BHF-UCL.
 GO:0006600; P:creatine metabolic process; ISS:BHF-UCL.
 GO:0046449; P:creatinine metabolic process; ISS:BHF-UCL.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0046543; P:development of secondary female sexual characteristics; IEA:Compara.
 GO:0046544; P:development of secondary male sexual characteristics; IEA:Compara.
 GO:0006631; P:fatty acid metabolic process; ISS:BHF-UCL.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0006549; P:isoleucine metabolic process; ISS:BHF-UCL.
 GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; IDA:BHF-UCL.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0019915; P:lipid storage; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0001553; P:luteinization; IEA:Compara.
 GO:0001779; P:natural killer cell differentiation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Compara.
 GO:0006107; P:oxaloacetate metabolic process; ISS:BHF-UCL.
 GO:0048541; P:Peyer's patch development; IEA:Compara.
 GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Compara.
 GO:0045579; P:positive regulation of B cell differentiation; IEA:Compara.
 GO:0051272; P:positive regulation of cellular component movement; IEA:Compara.
 GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Compara.
 GO:0050729; P:positive regulation of inflammatory response; IEA:Compara.
 GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Compara.
 GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
 GO:0040018; P:positive regulation of multicellular organism growth; IEA:Compara.
 GO:0032825; P:positive regulation of natural killer cell differentiation; IEA:Compara.
 GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Compara.
 GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0042448; P:progesterone metabolic process; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IEA:Compara.
 GO:0030856; P:regulation of epithelial cell differentiation; IEA:Compara.
 GO:0040014; P:regulation of multicellular organism growth; ISS:BHF-UCL.
 GO:0019218; P:regulation of steroid metabolic process; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IDA:BHF-UCL.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0070672; P:response to interleukin-15; IEA:Compara.
 GO:0070669; P:response to interleukin-2; IEA:Compara.
 GO:0070670; P:response to interleukin-4; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0006105; P:succinate metabolic process; ISS:BHF-UCL.
 GO:0033077; P:T cell differentiation in thymus; IEA:Compara.
 GO:0043029; P:T cell homeostasis; IEA:Compara.
 GO:0019530; P:taurine metabolic process; ISS:BHF-UCL.
 GO:0006366; P:transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006573; P:valine metabolic process; ISS:BHF-UCL. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR008967; p53-like_TF_DNA-bd.
 IPR000980; SH2.
 IPR013800; STAT_TF_alpha.
 IPR015988; STAT_TF_coiled-coil.
 IPR001217; STAT_TF_core.
 IPR013801; STAT_TF_DNA-bd.
 IPR012345; STAT_TF_DNA-bd_sub.
 IPR013799; STAT_TF_prot_interaction. 
Pfam
 PF00017; SH2
 PF01017; STAT_alpha
 PF02864; STAT_bind
 PF02865; STAT_int 
SMART
 SM00252; SH2
 SM00964; STAT_int 
PROSITE
 PS50001; SH2 
PRINTS