UniProt Accession

 CYPC_YEAST; P25719; D6W0K5 

Genbank Protein ID

 M84758; X56962; Z46373; AY557761; BK006946 

Genbank Nucleotide ID

 AAA34548.1; CAA40282.1; CAA86500.1; AAS56087.1; DAA09819.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase C, mitochondrial 

Protein Synonyms/Alias

 PPIase C; Cyclophilin C; PPI-III; Rotamase C 

Gene Name

 CPR3 

Gene Synonyms/Alias

 CYP3; YML078W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
34	DPAVNGTKIGRIEFE	acetylation	[1]
62	RALCTGEKGWGYKGV	acetylation	[1]
67	GEKGWGYKGVPFHRI	acetylation	[1]
100	GKSIYGSKFADENFV	acetylation	[1]
108	FADENFVKKHDKAGL	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This isozyme is required for growth on lactate at high temperature. 

Sequence Annotation

 DOMAIN 25 181 PPIase cyclophilin-type.  

Keyword

 Complete proteome; Cyclosporin; Direct protein sequencing; Isomerase; Mitochondrion; Reference proteome; Rotamase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0042277; F:peptide binding; IEA:UniProtKB-KW.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IDA:SGD.
 GO:0006915; P:apoptotic process; IMP:SGD.
 GO:0006457; P:protein folding; IDA:SGD. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR024936; Cyclophilin-type_PPIase.
 IPR020892; Cyclophilin-type_PPIase_CS. 

Pfam

 PF00160; Pro_isomerase 

SMART

  

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 

PRINTS

 PR00153; CSAPPISMRASE.