UniProt Accession

 IDHC_YEAST; P41939; D6VYH8 

Genbank Protein ID

 L26312; U17246; BK006945 

Genbank Nucleotide ID

 AAA64516.1; AAB67464.1; DAA09494.1 

Protein Name

 Isocitrate dehydrogenase [NADP] cytoplasmic 

Protein Synonyms/Alias

 IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase 

Gene Name

 IDP2 

Gene Synonyms/Alias

 YLR174W; L9470.12 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
260	DMVAQMLKSKGGYII	acetylation	[1]
354	DNTPDVVKFGQILES	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 

Functional Description

 May function in the production of NADPH for fatty acid and sterol synthesis. 

Sequence Annotation

 NP_BIND 75 77 NADP (By similarity).
 NP_BIND 310 315 NADP (By similarity).
 REGION 94 100 Substrate binding (By similarity).
 METAL 252 252 Magnesium or manganese (By similarity).
 METAL 275 275 Magnesium or manganese (By similarity).
 BINDING 77 77 Substrate (By similarity).
 BINDING 82 82 NADP (By similarity).
 BINDING 109 109 Substrate (By similarity).
 BINDING 132 132 Substrate (By similarity).
 BINDING 260 260 NADP (By similarity).
 BINDING 328 328 NADP; via amide nitrogen and carbonyl  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 412 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; TAS:SGD.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006537; P:glutamate biosynthetic process; TAS:SGD.
 GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
 GO:0006102; P:isocitrate metabolic process; IMP:SGD.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 

Interpro

 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR004790; Isocitrate_DH_NADP.
 IPR024084; IsoPropMal-DH-like_dom. 

Pfam

 PF00180; Iso_dh 

SMART

  

PROSITE

 PS00470; IDH_IMDH 

PRINTS