CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037320
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Guanylate cyclase soluble subunit beta-1 
Protein Synonyms/Alias
  
Gene Name
 GUCY1B3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
187HGTEIDMKVIQQRNEubiquitination[1]
583ETTGEKGKINVSEYTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 641 AA 
Protein Sequence
MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN 60
LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQK NESKHISDLH HCFLGIYLCC 120
NNLDALHDHL ATIYPGMRAP SFRCTDAEKG KGLILHYYSE REGLQDIVIG IIKTVAQQIH 180
GTEIDMKVIQ QRNEECDHTQ FLIEEKESKE EDFYEDLDRF EENGTQESRI SPYTFCKAFP 240
FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC SLLSVFSLVR PHIDISFHGI LSHINTVFVL 300
RSKEGLLDVE KLECEDELTG TEISCLRLKG QMIYLPEADS ILFLCSPSVM NLDDLTRRGL 360
YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE LEILTDRLQL TLRALEDEKK KTDTLLYSVL 420
PPSVANELRH KRPVPAKRYD NVTILFSGIV GFNAFCSKHA SGEGAMKIVN LLNDLYTRFD 480
TLTDSRKNPF VYKVETVGDK YMTVSGLPEP CIHHARSICH LALDMMEIAG QVQVDGESVQ 540
ITIGIHTGEV VTGVIGQRMP RYCLFGNTVN LTSRTETTGE KGKINVSEYT YRCLMSPENS 600
DPQFHLEHRG PVSMKGKKEP MQVWFLSRKN TGTEETKQDD D 641 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0004383; F:guanylate cyclase activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR011645; Haem_no_assoc-bd.
 IPR011644; Heme_NO-bd.
 IPR024096; NO_sig/Golgi_transp_ligand-bd. 
Pfam
 PF00211; Guanylate_cyc
 PF07700; HNOB
 PF07701; HNOBA 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS