UniProt Accession

 T10B_HUMAN; Q9Y5J6; Q96FF3 

Genbank Protein ID

 AF152355; AF150105; AF183415; BC011014 

Genbank Nucleotide ID

 AAF15105.1; AAD40011.1; AAG09684.1; AAH11014.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit Tim10 B 

Protein Synonyms/Alias

 Fracture callus protein 1; FxC1; Mitochondrial import inner membrane translocase subunit Tim9 B; TIMM10B; Tim10b 

Gene Name

 TIMM10B 

Gene Synonyms/Alias

 FXC1; TIM9B; TIMM9B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	CLHSCAGKLIHSNHR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. 

Sequence Annotation

 MOTIF 28 52 Twin CX3C motif.
 DISULFID 28 52 By similarity.
 DISULFID 32 48 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Protein transport; Reference proteome; Translocation; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:BHF-UCL.
 GO:0042719; C:mitochondrial intermembrane space protein transporter complex; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome. 

Interpro

 IPR004217; Tim10/DDP_fam_Znf. 

Pfam

 PF02953; zf-Tim10_DDP 

SMART

  

PROSITE

  

PRINTS