UniProt Accession

 ST38L_HUMAN; Q9Y2H1; A8K4U0; Q8TBX7 

Genbank Protein ID

 AB023182; AK291055; CH471094; BC028603 

Genbank Nucleotide ID

 BAA76809.2; BAF83744.1; EAW96549.1; AAH28603.1 

Protein Name

 Serine/threonine-protein kinase 38-like 

Protein Synonyms/Alias

 NDR2 protein kinase; Nuclear Dbf2-related kinase 2 

Gene Name

 STK38L 

Gene Synonyms/Alias

 KIAA0965; NDR2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
94	LDDFESLKVIGRGAF	ubiquitination	[1, 2]
110	EVRLVQKKDTGHIYA	ubiquitination	[2]
119	TGHIYAMKILRKSDM	ubiquitination	[2]
215	GFIHRDIKPDNLLLD	ubiquitination	[1]
224	DNLLLDAKGHVKLSD	ubiquitination	[1]
266	SFQNMNSKRKAETWK	ubiquitination	[2]
378	NSGVEEIKGHPFFEG	ubiquitination	[2]
460	GSIPTYMKAGKL***	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in the regulation of structural processes in differentiating and mature neuronal cells (By similarity). 

Sequence Annotation

 DOMAIN 90 383 Protein kinase.
 DOMAIN 384 453 AGC-kinase C-terminal.
 NP_BIND 96 104 ATP (By similarity).
 REGION 63 88 S100B binding (By similarity).
 ACT_SITE 213 213 Proton acceptor (By similarity).
 BINDING 119 119 ATP.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 75 75 Phosphothreonine.
 MOD_RES 282 282 Phosphoserine; by autocatalysis.
 MOD_RES 442 442 Phosphothreonine; by STK24/MST3.
 MOD_RES 450 450 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Actin-binding; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 464 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
 GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.
 GO:0051128; P:regulation of cellular component organization; ISS:UniProtKB. 

Interpro

 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase
 PF00433; Pkinase_C 

SMART

 SM00133; S_TK_X
 SM00220; S_TKc 

PROSITE

 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS