| Tag | Content |
|---|
| CPLM ID | CPLM-014326 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription factor 12 |
Protein Synonyms/Alias | TCF-12; Class A helix-loop-helix transcription factor ME1; DNA-binding protein HTF4; E-box-binding protein; Transcription factor HTF-4 |
Gene Name | Tcf12 |
Gene Synonyms/Alias | Alf1; Meb |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 543 | SVVPTEIKTENKEKD | acetylation | [1] |
|
Reference | [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C. PLoS One. 2012;7(12):e50545. [ PMID: 23236377] |
Functional Description | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). |
Sequence Annotation | DOMAIN 601 654 bHLH.
REGION 119 140 Leucine-zipper.
REGION 656 679 Class A specific domain.
MOTIF 181 188 Nuclear localization signal (Potential).
MOD_RES 67 67 Phosphoserine (By similarity).
MOD_RES 313 313 Phosphothreonine (By similarity).
MOD_RES 333 333 Phosphoserine (By similarity).
MOD_RES 581 581 Phosphothreonine (By similarity).
MOD_RES 583 583 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 706 AA |
Protein Sequence | MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG MDERGGTTSW 60
GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGTHEGLSPT PFMNSNLIGK TSERGSFSLY 120
SRDSGLSGCQ SSLLRQDLGL GSPAQLSSSG KPGTPYYSFS ATSSRRRPLH DSVALDPLQA 180
KKVRKVPPGL PSSVYAPSPN SDDFNRESPS YPSPKPPTSM FASTFFMQDG THSSSDLWSS 240
SNGMSQPGFG GILGTSTSHM SQSSSYGSLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG 300
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD HTSSSFPSNP 360
STPVGSPSPL TGTSQWPRAG GQAPSSPSYE NSLHSLKNRV EQQLHEHLQD AMSFLKDVCE 420
QSRMEDRLDR LDDAIHVLRN HAVGPSTSLP TSHSDIHSLL GPSHNASIGN LNSNYGGSSL 480
VTNSRSASMV GTHREDSVSL NGNHSVLSST VAASNTELNH KTPENFRGGV QNQSGSVVPT 540
EIKTENKEKD ENLHEPPSSD DMKSDDESSQ KDIKVSSRGR TSSTNEDEDL NPEQKIEREK 600
ERRMANNARE RLRVRDINEA FKELGRMCQL HLKSEKPQTK LLILHQAVAV ILSLEQQVRE 660
RNLNPKAACL KRREEEKVSA ASAEPPNTLP GAHPGLSEST NPMGHL 706 |
Gene Ontology | GO:0005667; C:transcription factor complex; IDA:MGI. GO:0070888; F:E-box binding; IDA:UniProtKB. GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara. GO:0045666; P:positive regulation of neuron differentiation; IDA:UniProtKB. GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |