UniProt Accession

 DNJA4_HUMAN; Q8WW22; E9PDM9; Q6AW87; Q8N5Z4; Q8N7P2 

Genbank Protein ID

 AK096616; AK098079; BX648710; AC092755; CH471136; BC021720; BC031044 

Genbank Nucleotide ID

 BAC04828.1; BAC05229.1; CAH10558.1; EAW99177.1; AAH21720.1; AAH31044.2 

Protein Name

 DnaJ homolog subfamily A member 4 

Protein Synonyms/Alias

  

Gene Name

 DNAJA4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
61	AYRKLALKYHPDKNP	ubiquitination	[1]
155	LYNGVTKKLALQKNV	ubiquitination	[2]
236	AKVIREKKIIEVHVE	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 DOMAIN 4 70 J.
 REPEAT 135 142 CXXCXGXG motif.
 REPEAT 151 158 CXXCXGXG motif.
 REPEAT 178 185 CXXCXGXG motif.
 REPEAT 194 201 CXXCXGXG motif.
 ZN_FING 122 206 CR-type.
 METAL 135 135 Zinc 1 (By similarity).
 METAL 138 138 Zinc 1 (By similarity).
 METAL 151 151 Zinc 2 (By similarity).
 METAL 154 154 Zinc 2 (By similarity).
 METAL 178 178 Zinc 2 (By similarity).
 METAL 181 181 Zinc 2 (By similarity).
 METAL 194 194 Zinc 1 (By similarity).
 METAL 197 197 Zinc 1 (By similarity).
 MOD_RES 394 394 Cysteine methyl ester (By similarity).
 LIPID 394 394 S-farnesyl cysteine (By similarity).  

Keyword

 Alternative splicing; Chaperone; Complete proteome; Lipoprotein; Membrane; Metal-binding; Methylation; Polymorphism; Prenylation; Reference proteome; Repeat; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 397 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0009408; P:response to heat; IEA:InterPro. 

Interpro

 IPR012724; DnaJ.
 IPR002939; DnaJ_C.
 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS.
 IPR008971; HSP40/DnaJ_pept-bd.
 IPR001305; HSP_DnaJ_Cys-rich_dom. 

Pfam

 PF00226; DnaJ
 PF01556; DnaJ_C
 PF00684; DnaJ_CXXCXGXG 

SMART

 SM00271; DnaJ 

PROSITE

 PS00636; DNAJ_1
 PS50076; DNAJ_2
 PS51188; ZF_CR 

PRINTS

 PR00625; JDOMAIN.