UniProt Accession

 KPYK1_SALTY; P77983 

Genbank Protein ID

 X99945; AE006468 

Genbank Nucleotide ID

 CAA68205.1; AAL20302.1 

Protein Name

 Pyruvate kinase I 

Protein Synonyms/Alias

 PK-1 

Gene Name

 pykF 

Gene Synonyms/Alias

 STM1378 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
421	GVVSQLVKEINSTDD	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 METAL 34 34 Potassium (By similarity).
 METAL 36 36 Potassium (By similarity).
 METAL 66 66 Potassium (By similarity).
 METAL 67 67 Potassium; via carbonyl oxygen (By
 METAL 222 222 Magnesium (By similarity).
 METAL 246 246 Magnesium (By similarity).
 BINDING 32 32 Substrate (By similarity).
 BINDING 245 245 Substrate; via amide nitrogen (By
 BINDING 246 246 Substrate; via amide nitrogen (By
 BINDING 278 278 Substrate (By similarity).  

Keyword

 Allosteric enzyme; ATP-binding; Complete proteome; Glycolysis; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Potassium; Pyruvate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 470 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030955; F:potassium ion binding; IEA:InterPro.
 GO:0004743; F:pyruvate kinase activity; IEA:EC.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001697; Pyr_Knase.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
 IPR011037; Pyrv_Knase-like_insert_dom.
 IPR015794; Pyrv_Knase_a/b.
 IPR018209; Pyrv_Knase_AS.
 IPR015793; Pyrv_Knase_brl.
 IPR015795; Pyrv_Knase_C.
 IPR015806; Pyrv_Knase_insert_dom. 

Pfam

 PF00224; PK
 PF02887; PK_C 

SMART

  

PROSITE

 PS00110; PYRUVATE_KINASE 

PRINTS

 PR01050; PYRUVTKNASE.