CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035769
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp25 
Gene Synonyms/Alias
 Usp25_predicted; rCG_58671 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
202RRLVLNYKPPSNAQDubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1055 AA 
Protein Sequence
MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDAQILQQAL KDSNGNLELA VAFLTAKNAK 60
TPPQEETAYY QTAALPGSDR YISVGSQADA NVIDLTGDDK DDLQRAIALS LAESNRTFRE 120
TGITDEEQAI SRVLEASIAE NKACLKRTPI EVWRDSRNPY DRKRQDKAPV GLKNVGNTCW 180
FSAVIQSLFN LLEFRRLVLN YKPPSNAQDL PRNQKEHRNL PFMRELRYLF ALLVGTKRKY 240
VDPSRAVEIL KDAFKSNDSQ QQDVSEFTHK LLDWLEDAFQ MKAEEETDEE KPKNPMVELF 300
YGRFLAMGVL EGKKFENTEM FGQYPLQVNG FKDLHECLEA AMIEGEIESL HSDNSGKSGQ 360
EHWFTELPPV LTFELSRFEF NQALGRPEKI HNKLEFPQVL YLDRYMHRNR EITRIKREEI 420
KRLKDYLTVL QQRLERYLSY GSGPKRFPLV DVLQYALEFA SSKPVCTSPV DDIDATSSTS 480
GSTSSQSLPS TTEQQGTPAS DLPSSSPASG AALSLRSVIH KPFTQSRIPP DLPMHPAPRH 540
ITEEELSVLE SCLHRWRTEI ENDTRDLQES ISRIHRTIEL MYSDKSMIQV PYRLHAVLVH 600
EGQANAGHYW AYIFDHRESR WMKYNDIAVT KSSWEELVRD SFGGYRNASA YCLMYINDKA 660
QFLIQEEFNK ETGQALVGME TLPPDLRDFV EEDNQRFEKE LEDWDTQLAQ RALQEKLLAA 720
QKLREAESSA PTAQAGGPDY LEQPSRSDLS KHWKEETLRV IAKASHDHED KGPETVLQSA 780
IKLEYSRLVK LAQEDTPPET DYRLHHVLVY FIQNQAPKKI IEKTLLEQFG DRNLSFDERC 840
HNIMKVAQAK LEMIKPEEVN LEEYEEWHAD YKKFRETTMY LIIGLENFQR ESYIDSLLFL 900
ICAYQNNKEL LSKGPYRGHD GDLISHYRRE CLLKLNEQAA ELFESGEDRE VSNGLIIMNE 960
FIVPFLPLLL VDETEERDIL AVEDMRNRWC SYLGQDMEPN LQEKLTDFLP KLLDCSTEIK 1020
GFHEPPKLPS YSAHELCERF ARIMLSLSRT PADGR 1055 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19.
 IPR009060; UBA-like.
 IPR003903; Ubiquitin-int_motif. 
Pfam
 PF00443; UCH
 PF02809; UIM 
SMART
 SM00726; UIM 
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3
 PS50330; UIM 
PRINTS