| Tag | Content |
|---|
| CPLM ID | CPLM-020372 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Epidermis-type lipoxygenase 3 |
Protein Synonyms/Alias | e-LOX-3 |
Gene Name | ALOXE3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 175 | DKKFALTKTTTCVDQ | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known. |
Sequence Annotation | DOMAIN 2 119 PLAT.
DOMAIN 120 711 Lipoxygenase.
METAL 408 408 Iron; catalytic (By similarity).
METAL 413 413 Iron; catalytic (By similarity).
METAL 588 588 Iron; catalytic (By similarity).
METAL 592 592 Iron; catalytic (By similarity).
METAL 711 711 Iron; via carboxylate; catalytic (By |
Keyword | Alternative splicing; Complete proteome; Dioxygenase; Disease mutation; Ichthyosis; Iron; Leukotriene biosynthesis; Metal-binding; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 711 AA |
Protein Sequence | MAVYRLCVTT GPYLRAGTLD NISVTLVGTC GESPKQRLDR MGRDFAPGSV QKYKVRCTAE 60
LGELLLLRVH KERYAFFRKD SWYCSRICVT EPDGSVSHFP CYQWIEGYCT VELRPGTART 120
ICQDSLPLLL DHRTRELRAR QECYRWKIYA PGFPCMVDVN SFQEMESDKK FALTKTTTCV 180
DQGDSSGNRY LPGFPMKIDI PSLMYMEPNV RYSATKTISL LFNAIPASLG MKLRGLLDRK 240
GSWKKLDDMQ NIFWCHKTFT TKYVTEHWCE DHFFGYQYLN GVNPVMLHCI SSLPSKLPVT 300
NDMVAPLLGQ DTCLQTELER GNIFLADYWI LAEAPTHCLN GRQQYVAAPL CLLWLSPQGA 360
LVPLAIQLSQ TPGPDSPIFL PTDSEWDWLL AKTWVRNSEF LVHENNTHFL CTHLLCEAFA 420
MATLRQLPLC HPIYKLLLPH TRYTLQVNTI ARATLLNPEG LVDQVTSIGR QGLIYLMSTG 480
LAHFTYTNFC LPDSLRARGV LAIPNYHYRD DGLKIWAAIE SFVSEIVGYY YPSDASVQQD 540
SELQAWTGEI FAQAFLGRES SGFPSRLCTP GEMVKFLTAI IFNCSAQHAA VNSGQHDFGA 600
WMPNAPSSMR QPPPQTKGTT TLKTYLDTLP EVNISCNNLL LFWLVSQEPK DQRPLGTYPD 660
EHFTEEAPRR SIAAFQSRLA QISRDIQERN QGLALPYTYL DPPLIENSVS I 711 |
Gene Ontology | GO:0005506; F:iron ion binding; IEA:InterPro. GO:0016165; F:lipoxygenase activity; IEA:InterPro. GO:0019370; P:leukotriene biosynthetic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |