CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004646
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrin beta-5 
Protein Synonyms/Alias
  
Gene Name
 ITGB5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
756HDRREFAKFQSERSRubiquitination[1]
792FTFNKFNKSYNGTVDubiquitination[2, 3]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. 
Sequence Annotation
 DOMAIN 27 76 PSI.
 DOMAIN 136 378 VWFA.
 REPEAT 465 512 I.
 REPEAT 513 554 II.
 REPEAT 555 593 III.
 REPEAT 594 630 IV.
 REGION 465 630 Cysteine-rich tandem repeats.
 CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
 CARBOHYD 460 460 N-linked (GlcNAc...) (Potential).
 CARBOHYD 477 477 N-linked (GlcNAc...) (Potential).
 CARBOHYD 505 505 N-linked (GlcNAc...) (Potential).
 CARBOHYD 552 552 N-linked (GlcNAc...) (Potential).
 CARBOHYD 586 586 N-linked (GlcNAc...) (Potential).
 CARBOHYD 654 654 N-linked (GlcNAc...) (Potential).
 CARBOHYD 705 705 N-linked (GlcNAc...) (Potential).
 DISULFID 28 463 By similarity.
 DISULFID 36 46 By similarity.
 DISULFID 39 75 By similarity.
 DISULFID 49 64 By similarity.
 DISULFID 202 211 By similarity.
 DISULFID 259 300 By similarity.
 DISULFID 401 413 By similarity.
 DISULFID 433 682 By similarity.
 DISULFID 461 465 By similarity.
 DISULFID 476 487 By similarity.
 DISULFID 484 522 By similarity.
 DISULFID 489 498 By similarity.
 DISULFID 500 513 By similarity.
 DISULFID 528 533 By similarity.
 DISULFID 530 563 By similarity.
 DISULFID 535 548 By similarity.
 DISULFID 550 555 By similarity.
 DISULFID 569 574 By similarity.
 DISULFID 571 602 By similarity.
 DISULFID 576 585 By similarity.
 DISULFID 587 594 By similarity.
 DISULFID 608 613 By similarity.
 DISULFID 610 657 By similarity.
 DISULFID 615 625 By similarity.
 DISULFID 628 631 By similarity.
 DISULFID 635 644 By similarity.
 DISULFID 641 714 By similarity.
 DISULFID 661 690 By similarity.  
Keyword
 Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Integrin; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 799 AA 
Protein Sequence
MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS KEDFGSPRSI 60
TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG SAGWDVIQMT PQEIAVNLRP 120
GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG 180
SFVDKDISPF SYTAPRYQTN PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS 240
RNRDAPEGGF DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC 300
HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA LIPGTTVEIL 360
DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT CQDGVSYPGQ RKCEGLKIGD 420
TASFEVSLEA RSCPSRHTEH VFALRPVGFR DSLEVGVTYN CTCGCSVGLE PNSARCNGSG 480
TYVCGLCECS PGYLGTRCEC QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF 540
GKIYGPFCEC DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ 600
ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG KPDNQTCHSL 660
CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP SGKSNLTVLR EPECGNTPNA 720
MTILLAVVGS ILLVGLALLA IWKLLVTIHD RREFAKFQSE RSRARYEMAS NPLYRKPIST 780
HTVDFTFNKF NKSYNGTVD 799 
Gene Ontology
 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0008305; C:integrin complex; IEA:InterPro.
 GO:0045335; C:phagocytic vesicle; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0030198; P:extracellular matrix organization; TAS:Reactome.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:InterPro.
 GO:0006936; P:muscle contraction; TAS:Reactome. 
Interpro
 IPR000742; EG-like_dom.
 IPR027067; Integrin_beta-5.
 IPR015812; Integrin_bsu.
 IPR014836; Integrin_bsu_cyt_dom.
 IPR002369; Integrin_bsu_N.
 IPR012896; Integrin_bsu_tail.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002035; VWF_A. 
Pfam
 PF08725; Integrin_b_cyt
 PF07965; Integrin_B_tail
 PF00362; Integrin_beta 
SMART
 SM00181; EGF
 SM00187; INB
 SM00423; PSI
 SM00327; VWA 
PROSITE
 PS00022; EGF_1
 PS01186; EGF_2
 PS00243; INTEGRIN_BETA
 PS50234; VWFA 
PRINTS
 PR01186; INTEGRINB.