| Tag | Content |
|---|
| CPLM ID | CPLM-019060 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RAD51-associated protein 1 |
Protein Synonyms/Alias | RAD51-interacting protein |
Gene Name | RAD51AP1 |
Gene Synonyms/Alias | PIR51 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 343 | LSRLARVKPLHPNAT | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA. |
Sequence Annotation | REGION 313 352 Interaction with RAD51.
MOD_RES 19 19 Phosphoserine.
MOD_RES 21 21 Phosphoserine.
MOD_RES 120 120 Phosphoserine.
MOD_RES 280 280 Phosphoserine.
MOD_RES 327 327 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 352 AA |
Protein Sequence | MVRPVRHKKP VNYSQFDHSD SDDDFVSATV PLNKKSRTAP KELKQDKPKP NLNNLRKEEI 60
PVQEKTPKKR LPEGTFSIPA SAVPCTKMAL DDKLYQRDLE VALALSVKEL PTVTTNVQNS 120
QDKSIEKHGS SKIETMNKSP HISNCSVASD YLDLDKITVE DDVGGVQGKR KAASKAAAQQ 180
RKILLEGSDG DSANDTEPDF APGEDSEDDS DFCESEDNDE DFSMRKSKVK EIKKKEVKVK 240
SPVEKKEKKS KSKCNALVTS VDSAPAAVKS ESQSLPKKVS LSSDTTRKPL EIRSPSAESK 300
KPKWVPPAAS GGSRSSSSPL VVVSVKSPNQ SLRLGLSRLA RVKPLHPNAT ST 352 |
Gene Ontology | GO:0005634; C:nucleus; IC:UniProtKB. GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB. GO:0003723; F:RNA binding; IDA:UniProtKB. GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB. GO:0000724; P:double-strand break repair via homologous recombination; NAS:UniProtKB. |
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PRINTS | |