UniProt Accession

 IGJ_HUMAN; P01591 

Genbank Protein ID

 AK312014; M12759; M12378 

Genbank Nucleotide ID

 BAG34952.1; AAA58902.1; AAA58902.1 

Protein Name

 Immunoglobulin J chain 

Protein Synonyms/Alias

  

Gene Name

 IGJ 

Gene Synonyms/Alias

 IGCJ 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	FIKAVHVKAQEDERI	ubiquitination	[1]
34	RIVLVDNKCKCARIT	ubiquitination	[1]
36	VLVDNKCKCARITSR	ubiquitination	[1]
92	YHLSDLCKKCDPTEV	ubiquitination	[1]
130	CYTYDRNKCYTAVVP	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component. 

Sequence Annotation

 MOD_RES 23 23 Pyrrolidone carboxylic acid.
 CARBOHYD 71 71 N-linked (GlcNAc...).
 DISULFID 35 123
 DISULFID 37 37 Interchain (with heavy chain).
 DISULFID 91 91 Interchain (with heavy chain).
 DISULFID 94 114
 DISULFID 131 156  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 159 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0003823; F:antigen binding; NAS:UniProtKB.
 GO:0006955; P:immune response; NAS:UniProtKB. 

Interpro

 IPR024110; Ig_J. 

Pfam

  

SMART

  

PROSITE

  

PRINTS