| Tag | Content |
|---|
| CPLM ID | CPLM-014986 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tyrosine-protein kinase STYK1 |
Protein Synonyms/Alias | Novel oncogene with kinase domain; Protein PK-unique; Serine/threonine/tyrosine kinase 1 |
Gene Name | STYK1 |
Gene Synonyms/Alias | NOK |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 105 | ATTPALAKLQVPREQ | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). |
Sequence Annotation | DOMAIN 114 384 Protein kinase.
NP_BIND 120 128 ATP (By similarity).
ACT_SITE 251 251 Proton acceptor (By similarity).
BINDING 147 147 ATP (By similarity). |
Keyword | ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Polymorphism; Proto-oncogene; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 422 AA |
Protein Sequence | MGMTRMLLEC SLSDKLCVIQ EKQYEVIIVP TLLVTIFLIL LGVILWLFIR EQRTQQQRSG 60
PQGIAPVPPP RDLSWEAGHG GNVALPLKET SVENFLGATT PALAKLQVPR EQLSEVLEQI 120
CSGSCGPIFR ANMNTGDPSK PKSVILKALK EPAGLHEVQD FLGRIQFHQY LGKHKNLVQL 180
EGCCTEKLPL YMVLEDVAQG DLLSFLWTCR RDVMTMDGLL YDLTEKQVYH IGKQVLLALE 240
FLQEKHLFHG DVAARNILMQ SDLTAKLCGL GLAYEVYTRG AISSTQTIPL KWLAPERLLL 300
RPASIRADVW SFGILLYEMV TLGAPPYPEV PPTSILEHLQ RRKIMKRPSS CTHTMYSIMK 360
SCWRWREADR PSPRELRLRL EAAIKTADDE AVLQVPELVV PELYAAVAGI RVESLFYNYS 420
ML 422 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IDA:LIFEdb. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. |
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SMART | |
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