UniProt Accession

 BL1S2_HUMAN; Q6QNY1; B4DQV2; Q5W040; Q8WUI8 

Genbank Protein ID

 AY531265; AY278457; AK298969; AL138921; AL139819; AL139819; AL138921; CH471066; BC020494 

Genbank Nucleotide ID

 AAT00461.1; AAQ19606.1; BAG61064.1; CAH72396.1; CAH72396.1; CAH72821.1; CAH72821.1; EAW49836.1; AAH20494.1 

Protein Name

 Biogenesis of lysosome-related organelles complex 1 subunit 2 

Protein Synonyms/Alias

 BLOC-1 subunit 2; Centrosome-associated protein 

Gene Name

 BLOC1S2 

Gene Synonyms/Alias

 BLOS2; CEAP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
76	MNKLTSLKYLEMKDI	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in cell proliferation. 

Sequence Annotation

  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0031083; C:BLOC-1 complex; IDA:UniProtKB.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0000930; C:gamma-tubulin complex; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0055037; C:recycling endosome; IEA:Compara.
 GO:0043015; F:gamma-tubulin binding; IDA:UniProtKB.
 GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IDA:UniProtKB.
 GO:0032438; P:melanosome organization; NAS:UniProtKB.
 GO:0007020; P:microtubule nucleation; NAS:UniProtKB.
 GO:0097345; P:mitochondrial outer membrane permeabilization; IDA:UniProtKB.
 GO:0031175; P:neuron projection development; ISS:UniProtKB.
 GO:0060155; P:platelet dense granule organization; NAS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB. 

Interpro

 IPR019269; BLOC1_su2. 

Pfam

 PF10046; BLOC1_2 

SMART

  

PROSITE

  

PRINTS