UniProt Accession

 BIEA_RAT; P46844 

Genbank Protein ID

 M81681 

Genbank Nucleotide ID

 AAA40830.1 

Protein Name

 Biliverdin reductase A 

Protein Synonyms/Alias

 BVR A; Biliverdin-IX alpha-reductase 

Gene Name

 Blvra 

Gene Synonyms/Alias

 Blvr 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
142	LRREVLGKELLKGSL	acetylation	[1]
146	VLGKELLKGSLRFTA	acetylation	[1]
218	LLSWIEEKGPGLKRN	acetylation	[1]
252	VNKNIFLKDQDIFVQ	acetylation	[1]
274	AEDLAAEKKRIMHCL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. 

Sequence Annotation

 NP_BIND 15 20 NAD or NADP.
 NP_BIND 76 79 NAD or NADP.
 METAL 279 279 Zinc (Potential).
 METAL 280 280 Zinc (Potential).
 METAL 291 291 Zinc (Potential).
 METAL 292 292 Zinc (Potential).
 BINDING 97 97 NAD or NADP; via carbonyl oxygen.
 MOD_RES 173 173 Phosphothreonine (By similarity).
 MOD_RES 177 177 Phosphoserine (By similarity).
 MOD_RES 247 247 N6-acetyllysine (By similarity).
 MOD_RES 252 252 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Metal-binding; NAD; NADP; Oxidoreductase; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004074; F:biliverdin reductase activity; TAS:RGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042167; P:heme catabolic process; IEA:InterPro. 

Interpro

 IPR017094; Biliverdin_Rdtase_A.
 IPR015249; Biliverdin_Rdtase_cat.
 IPR016040; NAD(P)-bd_dom.
 IPR000683; Oxidoreductase_N. 

Pfam

 PF09166; Biliv-reduc_cat
 PF01408; GFO_IDH_MocA 

SMART

  

PROSITE

  

PRINTS