CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025276
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 4-trimethylaminobutyraldehyde dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 Aldh9a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
54VDASGTEKAFEPATGacetylation[1, 2, 3, 4, 5, 6, 7]
54VDASGTEKAFEPATGsuccinylation[6]
54VDASGTEKAFEPATGubiquitination[8]
73TFACSGEKEVNLAVEubiquitination[8]
83NLAVENAKAAFKLWSacetylation[6]
83NLAVENAKAAFKLWSsuccinylation[6]
83NLAVENAKAAFKLWSubiquitination[8]
87ENAKAAFKLWSKKSGacetylation[7]
112ARIIKERKDEIATVEubiquitination[8]
251CHHREVAKISFTGSVubiquitination[8]
263GSVPTGVKIMEMSAKubiquitination[8]
270KIMEMSAKGVKPITLacetylation[6]
270KIMEMSAKGVKPITLsuccinylation[6]
270KIMEMSAKGVKPITLubiquitination[8]
282ITLELGGKSPLIIFSubiquitination[8]
322GTRVFVQKEIADKFIacetylation[1, 2, 5, 7]
322GTRVFVQKEIADKFIubiquitination[8]
327VQKEIADKFINEVVKacetylation[1, 2, 3, 5, 6, 7]
327VQKEIADKFINEVVKsuccinylation[6]
327VQKEIADKFINEVVKubiquitination[8]
334KFINEVVKQTQKIKLacetylation[1, 4, 7]
334KFINEVVKQTQKIKLubiquitination[8]
338EVVKQTQKIKLGDPLacetylation[7]
340VKQTQKIKLGDPLLEacetylation[7]
340VKQTQKIKLGDPLLEubiquitination[8]
368ERVLGFVKLAKEQGAacetylation[5, 7]
368ERVLGFVKLAKEQGAubiquitination[8]
371LGFVKLAKEQGATVLacetylation[7]
390VYVPEDPKLKHGYYMacetylation[1]
392VPEDPKLKHGYYMTPacetylation[5, 7]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [5] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [7] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [8] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 518 AA 
Protein Sequence
MILGAVGSVL TSLLRIHRAA AVAAMSTGTF VVSQPLNYRG GARVEPVDAS GTEKAFEPAT 60
GRVIATFACS GEKEVNLAVE NAKAAFKLWS KKSGLERCQV LLEAARIIKE RKDEIATVET 120
INNGKSIFEA RLDVDTCWQC LEYYAGLAAS MAGEHIQLPG GSFGYTRREP LGVCVGIGAW 180
NYPFQIACWK SAPALACGNA MIFKPSPFTP VSALLLAEIY TKAGAPPGLF NVVQGGAATG 240
QFLCHHREVA KISFTGSVPT GVKIMEMSAK GVKPITLELG GKSPLIIFSD CNMENAVKGA 300
LMANFLTQGQ VCCNGTRVFV QKEIADKFIN EVVKQTQKIK LGDPLLEDTR MGPLINAPHL 360
ERVLGFVKLA KEQGATVLCG GEVYVPEDPK LKHGYYMTPC ILTNCRDDMT CVKEEIFGPV 420
MSILTFGTEA EVLERANDTT FGLAAGVFTR DIQRAHRVAA ELQAGTCYIN NYNVSPVELP 480
FGGYKKSGFG RENGRVTIEY YSQLKTVCVE MGDVESAF 518 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0019145; F:aminobutyraldehyde dehydrogenase activity; IEA:Compara.
 GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IDA:MGI.
 GO:0009437; P:carnitine metabolic process; IDA:MGI.
 GO:0006081; P:cellular aldehyde metabolic process; IEA:Compara.
 GO:0042136; P:neurotransmitter biosynthetic process; IEA:Compara. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS