CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011710
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cingulin-like protein 1 
Protein Synonyms/Alias
 Junction-associated coiled-coil protein; Paracingulin 
Gene Name
 CGNL1 
Gene Synonyms/Alias
 JACOP; KIAA1749 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
525GAKKISVKTFPSASNubiquitination[1]
681ESEGELRKNLEELFQubiquitination[1]
1052LEYELEAKSHLKDDRacetylation[2]
1064DDRSRLVKQMEDKVSacetylation[2]
1069LVKQMEDKVSQLEMEacetylation[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons (By similarity). 
Sequence Annotation
 REGION 1 554 Head.
 REGION 1263 1302 Tail.
 MOTIF 37 51 ZIM (By similarity).
 MOD_RES 283 283 Phosphoserine.
 MOD_RES 297 297 Phosphoserine.
 MOD_RES 298 298 Phosphoserine.
 MOD_RES 388 388 Phosphoserine (By similarity).
 MOD_RES 391 391 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Cell junction; Chromosomal rearrangement; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Tight junction. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1302 AA 
Protein Sequence
MELYFGEYQH VQQEYGVHLR LASDDTQKSR SSQNSKAGSY GVSIRVQGID GHPYIVLNNT 60
ERCLAGTSFS ENGPPFPPPV INNLPLHSSN GSVPKENSEE LQLPENPYAQ PSPIRNLKQP 120
LLHEGKNGVL DRKDGSVKPS HLLNFQRHPE LLQPYDPEKN ELNLQNHQPS ESNWLKTLTE 180
EGINNKKPWT CFPKPSNSQP TSPSLEDPAK SGVTAIRLCS SVVIEDPKKQ TSVCVNVQSC 240
TKERVGEEAL FTSGRPLTAH SPHAHPETKK TRPDVLPFRR QDSAGPVLDG ARSRRSSSSS 300
TTPTSANSLY RFLLDDQECA IHADNVNRHE NRRYIPFLPG TGRDIDTGSI PGVDQLIEKF 360
DQKPGLQRRG RSGKRNRINT DDRKRSRSVD SAFPFGLQGN SEYLIEFSRN LGKSSEHLLR 420
PSQVCPQRPL SQERRGKQSV GRTFAKLQGA AHGASCAHSR PPQPNIDGKV LETEGSQEST 480
VIRAPSLGAQ SKKEEEVKTA TATLMLQNRA TATSPDSGAK KISVKTFPSA SNTQATPDLL 540
KGQQELTQQT NEETAKQILY NYLKEGSTDN DDATKRKVNL VFEKIQTLKS RAAGSAQGNN 600
QACNSTSEVK DLLEQKSKLT IEVAELQRQL QLEVKNQQNI KEERERMRAN LEELRSQHNE 660
KVEENSTLQQ RLEESEGELR KNLEELFQVK MEREQHQTEI RDLQDQLSEM HDELDSAKRS 720
EDREKGALIE ELLQAKQDLQ DLLIAKEEQE DLLRKREREL TALKGALKEE VSSHDQEMDK 780
LKEQYDAELQ ALRESVEEAT KNVEVLASRS NTSEQDQAGT EMRVKLLQEE NEKLQGRSEE 840
LERRVAQLQR QIEDLKGDEA KAKETLKKYE GEIRQLEEAL VHARKEEKEA VSARRALENE 900
LEAAQGNLSQ TTQEQKQLSE KLKEESEQKE QLRRLKNEME NERWHLGKTI EKLQKEMADI 960
VEASRTSTLE LQNQLDEYKE KNRRELAEMQ RQLKEKTLEA EKSRLTAMKM QDEMRLMEEE 1020
LRDYQRAQDE ALTKRQLLEQ TLKDLEYELE AKSHLKDDRS RLVKQMEDKV SQLEMELEEE 1080
RNNSDLLSER ISRSREQMEQ LRNELLQERA ARQDLECDKI SLERQNKDLK SRIIHLEGSY 1140
RSSKEGLVVQ MEARIAELED RLESEERDRA NLQLSNRRLE RKVKELVMQV DDEHLSLTDQ 1200
KDQLSLRLKA MKRQVEEAEE EIDRLESSKK KLQRELEEQM DMNEHLQGQL NSMKKDLRLK 1260
KLPSKVLDDM DDDDDLSTDG GSLYEAPVSY TFSKDSTVAS QI 1302 
Gene Ontology
 GO:0016459; C:myosin complex; IEA:InterPro.
 GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR002928; Myosin_tail. 
Pfam
 PF01576; Myosin_tail_1 
SMART
  
PROSITE
  
PRINTS