CPLM-005503

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-005503

UniProt Accession

ELAV4_HUMAN; P26378; B1APY6; B1APY7; B7Z4G7; Q8IYD4; Q96J74; Q96J75; Q9UD24

Genbank Protein ID

M62843; AY033995; AY033996; AY033997; AY033998; AK297338; AL583843; AL592182; AL583843; AL592182; AL583843; AL592182; AL583843; AL592182; AL592182; AL583843; AL592182; AL583843; AL592182; AL583843; AL592182; AL583843; AL645730; AL731870; CH471059; BC036071

Genbank Nucleotide ID

AAA58396.1; AAK57538.1; AAK57539.1; AAK57540.1; AAK57541.1; BAH12553.1; CAI14634.1; CAI14634.1; CAI14635.1; CAI14635.1; CAI14636.1; CAI14636.1; CAI14637.1; CAI14637.1; CAI15788.1; CAI15788.1; CAI15789.1; CAI15789.1; CAI15790.1; CAI15790.1; CAI15791.1; CAI15791.1; EAX06845.1; AAH36071.1

Protein Name

ELAV-like protein 4

Protein Synonyms/Alias

Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD

Gene Name

ELAVL4

Gene Synonyms/Alias

HUD; PNEM

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
81	SCKLVRDKITGQSLG	ubiquitination	[1]
102	IDPKDAEKAINTLNG	ubiquitination	[1]
146	LPKTMTQKELEQLFS	ubiquitination	[1]
216	FANNPSQKSSQALLS	ubiquitination	[1]
257	LNMAYGVKRFSPITI	ubiquitination	[1]
359	RVLQVSFKTNKAHKS	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.

Sequence Annotation

DOMAIN 46 124 RRM 1.
DOMAIN 132 212 RRM 2.
DOMAIN 297 375 RRM 3.
MOD_RES 243 243 Omega-N-methylated arginine; by CARM1.

Keyword

3D-structure; Alternative splicing; Complete proteome; Methylation; Polymorphism; Reference proteome; Repeat; RNA-binding.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

380 AA

Protein Sequence

MVMIISTMEP QVSNGPTSNT SNGPSSNNRN CPSPMQTGAT TDDSKTNLIV NYLPQNMTQE 60
EFRSLFGSIG EIESCKLVRD KITGQSLGYG FVNYIDPKDA EKAINTLNGL RLQTKTIKVS 120
YARPSSASIR DANLYVSGLP KTMTQKELEQ LFSQYGRIIT SRILVDQVTG VSRGVGFIRF 180
DKRIEAEEAI KGLNGQKPSG ATEPITVKFA NNPSQKSSQA LLSQLYQSPN RRYPGPLHHQ 240
AQRFRLDNLL NMAYGVKRFS PITIDGMTSL VGMNIPGHTG TGWCIFVYNL SPDSDESVLW 300
QLFGPFGAVN NVKVIRDFNT NKCKGFGFVT MTNYDEAAMA IASLNGYRLG DRVLQVSFKT 360
NKAHKS 366

Gene Ontology

GO:0017091; F:AU-rich element binding; IDA:UniProtKB.
GO:0003730; F:mRNA 3'-UTR binding; TAS:ProtInc.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006397; P:mRNA processing; TAS:ProtInc.

Interpro

IPR006548; ELAD_HUD_SF.
IPR002343; Hud_Sxl_RNA.
IPR012677; Nucleotide-bd_a/b_plait.
IPR000504; RRM_dom.

Pfam

PF00076; RRM_1

SMART

SM00360; RRM

PROSITE

PS50102; RRM

PRINTS

PR00961; HUDSXLRNA.