UniProt Accession

 E9PV44_MOUSE; E9PV44 

Genbank Protein ID

 AL805897 

Genbank Nucleotide ID

  

Protein Name

 ATPase inhibitor, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Atpif1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	EAGGAFGKREKAEED	acetylation	[1, 2]
17	EAGGAFGKREKAEED	succinylation	[2]
32	RYFREKTKEQLAALR	acetylation	[1, 3]
32	RYFREKTKEQLAALR	ubiquitination	[4]
51	DEIDHHSKEIERLQK	acetylation	[1, 3, 5]
58	KEIERLQKQIERHKK	acetylation	[2, 3, 6]
58	KEIERLQKQIERHKK	succinylation	[2]
71	KKKIQQLKNNH****	acetylation	[2, 3, 6]
71	KKKIQQLKNNH****	succinylation	[2]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 74 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004857; F:enzyme inhibitor activity; IEA:InterPro.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0006783; P:heme biosynthetic process; IEA:Compara.
 GO:0043086; P:negative regulation of catalytic activity; IEA:GOC.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Compara.
 GO:0045980; P:negative regulation of nucleotide metabolic process; IEA:InterPro.
 GO:0072593; P:reactive oxygen species metabolic process; IMP:MGI.
 GO:0042981; P:regulation of apoptotic process; IMP:MGI. 

Interpro

 IPR007648; ATPase_inhibitor_IATP_mt. 

Pfam

 PF04568; IATP 

SMART

  

PROSITE

  

PRINTS