Tag | Content |
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CPLM ID | CPLM-002306 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NAD(P)H dehydrogenase [quinone] 1 |
Protein Synonyms/Alias | Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD(P)H:quinone oxidoreductase 1; Phylloquinone reductase; Quinone reductase 1; QR1 |
Gene Name | Nqo1 |
Gene Synonyms/Alias | Nmor1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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31 | EAAVEALKKKGWEVV | acetylation | [1] | 61 | NDITGEPKDSENFQY | acetylation | [1] | 77 | VESSLAYKEGRLSPD | acetylation | [1] | 90 | PDIVAEQKKLEAADL | acetylation | [1] | 249 | EVQEEQKKNKFGLSV | acetylation | [1] | 251 | QEEQKKNKFGLSVGH | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. |
Sequence Annotation | NP_BIND 18 19 FAD. NP_BIND 104 107 FAD. NP_BIND 148 151 FAD. REGION 126 128 Substrate binding (By similarity). BINDING 12 12 FAD. BINDING 67 67 FAD. BINDING 156 156 FAD. BINDING 201 201 FAD. MOD_RES 2 2 N-acetylalanine. |
Keyword | 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; FAD; Flavoprotein; NAD; NADP; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 274 AA |
Protein Sequence | MAVRRALIVL AHAERTSFNY AMKEAAVEAL KKKGWEVVES DLYAMNFNPL ISRNDITGEP 60 KDSENFQYPV ESSLAYKEGR LSPDIVAEQK KLEAADLVIF QFPLYWFGVP AILKGWFERV 120 LVAGFAYTYA TMYDKGPFQN KKTLLSITTG GSGSMYSLQG VHGDMNVILW PIQSGILRFC 180 GFQVLEPQLV YSIGHTPPDA RVQVLEGWKK RLETVWEESP LYFAPSSLFD LNFQAGFLLK 240 KEVQEEQKKN KFGLSVGHHL GKSIPADNQI KARK 274 |
Gene Ontology | GO:0005829; C:cytosol; IDA:RGD. GO:0043025; C:neuronal cell body; IDA:RGD. GO:0003955; F:NAD(P)H dehydrogenase (quinone) activity; IDA:RGD. GO:0004784; F:superoxide dismutase activity; IMP:RGD. GO:0007568; P:aging; IEP:RGD. GO:0043086; P:negative regulation of catalytic activity; IEA:Compara. GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD. GO:0032355; P:response to estradiol stimulus; IEP:RGD. GO:0045471; P:response to ethanol; IEP:RGD. GO:0007584; P:response to nutrient; IEP:RGD. GO:0006979; P:response to oxidative stress; IEP:RGD. GO:0006801; P:superoxide metabolic process; IMP:RGD. |
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