CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002306
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NAD(P)H dehydrogenase [quinone] 1 
Protein Synonyms/Alias
 Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD(P)H:quinone oxidoreductase 1; Phylloquinone reductase; Quinone reductase 1; QR1 
Gene Name
 Nqo1 
Gene Synonyms/Alias
 Nmor1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
31EAAVEALKKKGWEVVacetylation[1]
61NDITGEPKDSENFQYacetylation[1]
77VESSLAYKEGRLSPDacetylation[1]
90PDIVAEQKKLEAADLacetylation[1]
249EVQEEQKKNKFGLSVacetylation[1]
251QEEQKKNKFGLSVGHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. 
Sequence Annotation
 NP_BIND 18 19 FAD.
 NP_BIND 104 107 FAD.
 NP_BIND 148 151 FAD.
 REGION 126 128 Substrate binding (By similarity).
 BINDING 12 12 FAD.
 BINDING 67 67 FAD.
 BINDING 156 156 FAD.
 BINDING 201 201 FAD.
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; FAD; Flavoprotein; NAD; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 274 AA 
Protein Sequence
MAVRRALIVL AHAERTSFNY AMKEAAVEAL KKKGWEVVES DLYAMNFNPL ISRNDITGEP 60
KDSENFQYPV ESSLAYKEGR LSPDIVAEQK KLEAADLVIF QFPLYWFGVP AILKGWFERV 120
LVAGFAYTYA TMYDKGPFQN KKTLLSITTG GSGSMYSLQG VHGDMNVILW PIQSGILRFC 180
GFQVLEPQLV YSIGHTPPDA RVQVLEGWKK RLETVWEESP LYFAPSSLFD LNFQAGFLLK 240
KEVQEEQKKN KFGLSVGHHL GKSIPADNQI KARK 274 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0003955; F:NAD(P)H dehydrogenase (quinone) activity; IDA:RGD.
 GO:0004784; F:superoxide dismutase activity; IMP:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0043086; P:negative regulation of catalytic activity; IEA:Compara.
 GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0006979; P:response to oxidative stress; IEP:RGD.
 GO:0006801; P:superoxide metabolic process; IMP:RGD. 
Interpro
 IPR003680; Flavodoxin_fold. 
Pfam
 PF02525; Flavodoxin_2 
SMART
  
PROSITE
  
PRINTS