UniProt Accession

 ZDHC7_HUMAN; Q9NXF8; D3DUM1; Q8WV42; Q9NVD8 

Genbank Protein ID

 AK000286; AK001654; CH471114; CH471114; BC017702; BC018772 

Genbank Nucleotide ID

 BAA91055.1; BAA91814.1; EAW95464.1; EAW95465.1; AAH17702.1; AAH18772.1 

Protein Name

 Palmitoyltransferase ZDHHC7 

Protein Synonyms/Alias

 Zinc finger DHHC domain-containing protein 7; DHHC-7; Zinc finger protein 370 

Gene Name

 ZDHHC7 

Gene Synonyms/Alias

 ZNF370 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
110	TDPGAVPKGNATKEY	ubiquitination	[1]
256	ETEIERLKSEKPTWE	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors. 

Sequence Annotation

 ZN_FING 130 180 DHHC-type.  

Keyword

 Acyltransferase; Alternative splicing; Complete proteome; Golgi apparatus; Membrane; Metal-binding; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 308 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016409; F:palmitoyltransferase activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IMP:UniProtKB. 

Interpro

 IPR001594; Znf_DHHC_palmitoyltrfase. 

Pfam

 PF01529; zf-DHHC 

SMART

  

PROSITE

 PS50216; ZF_DHHC 

PRINTS