UniProt Accession

 ANXA1_MOUSE; P10107 

Genbank Protein ID

 X07486; M69260; M69250; M69251; M69252; M69253; M69254; M69255; M69256; M69257; M69258; M69259; BC002289; BC004594; M24554 

Genbank Nucleotide ID

 CAA30371.1; AAA39437.1; AAA39437.1; AAA39437.1; AAA39437.1; AAA39437.1; AAA39437.1; AAA39437.1; AAA39437.1; AAA39437.1; AAA39437.1; AAA39437.1; AAH02289.1; AAH04594.1; AAA39420.1 

Protein Name

 Annexin A1 

Protein Synonyms/Alias

 Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35 

Gene Name

 Anxa1 

Gene Synonyms/Alias

 Anx1; Lpc-1; Lpc1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	AMVSEFLKQARFLEN	acetylation	[1, 2]
26	QEYVQAVKSYKGGPG	acetylation	[1, 2]
26	QEYVQAVKSYKGGPG	ubiquitination	[3]
29	VQAVKSYKGGPGSAV	acetylation	[2, 4]
53	SDVAALHKAIMVKGV	acetylation	[1]
58	LHKAIMVKGVDEATI	acetylation	[1, 4]
71	TIIDILTKRTNAQRQ	acetylation	[1]
90	AYLQENGKPLDEVLR	acetylation	[2]
166	ELKRDLAKDITSDTS	acetylation	[1, 2]
166	ELKRDLAKDITSDTS	ubiquitination	[3]
185	KALLALAKGDRCQDL	acetylation	[1, 2]
242	RVFQNYGKYSQHDMN	acetylation	[1, 2]
250	YSQHDMNKALDLELK	acetylation	[1, 2]
262	ELKGDIEKCLTTIVK	acetylation	[1]
312	EIDMNEIKVFYQKKY	acetylation	[1, 2, 4, 5]
318	IKVFYQKKYGISLCQ	acetylation	[1]
332	QAILDETKGDYEKIL	acetylation	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity. 

Sequence Annotation

 REPEAT 51 111 Annexin 1.
 REPEAT 123 183 Annexin 2.
 REPEAT 207 267 Annexin 3.
 REPEAT 282 342 Annexin 4.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 5 5 Phosphoserine; by TRPM7 (By similarity).
 MOD_RES 21 21 Phosphotyrosine.
 MOD_RES 27 27 Phosphoserine; by PKC (By similarity).
 MOD_RES 37 37 Phosphoserine (By similarity).
 MOD_RES 312 312 N6-acetyllysine (By similarity).
 CROSSLNK 19 19 Isoglutamyl lysine isopeptide (Gln-Lys)  

Keyword

 Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Cell membrane; Cell projection; Cilium; Complete proteome; Cytoplasm; Isopeptide bond; Membrane; Nucleus; Phospholipase A2 inhibitor; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
 GO:0001533; C:cornified envelope; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0031966; C:mitochondrial membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; IEA:Compara.
 GO:0046632; P:alpha-beta T cell differentiation; IMP:BHF-UCL.
 GO:0050482; P:arachidonic acid secretion; IMP:MGI.
 GO:0007166; P:cell surface receptor signaling pathway; IEA:Compara.
 GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0031018; P:endocrine pancreas development; IEA:Compara.
 GO:0060206; P:estrous cycle phase; IEA:Compara.
 GO:0042063; P:gliogenesis; IEA:Compara.
 GO:0070365; P:hepatocyte differentiation; IEA:Compara.
 GO:0030073; P:insulin secretion; IEA:Compara.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0002674; P:negative regulation of acute inflammatory response; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0050709; P:negative regulation of protein secretion; IEA:Compara.
 GO:0097350; P:neutrophil clearance; IEA:Compara.
 GO:0001780; P:neutrophil homeostasis; IMP:BHF-UCL.
 GO:0018149; P:peptide cross-linking; IEA:Compara.
 GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IMP:MGI.
 GO:0033031; P:positive regulation of neutrophil apoptotic process; IMP:BHF-UCL.
 GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IEA:Compara.
 GO:0031340; P:positive regulation of vesicle fusion; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IMP:MGI.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0070555; P:response to interleukin-1; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0010165; P:response to X-ray; IEA:Compara.
 GO:0007165; P:signal transduction; IMP:MGI. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002388; AnnexinI. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00197; ANNEXINI.