CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015736
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome c oxidase assembly protein COX15 homolog 
Protein Synonyms/Alias
  
Gene Name
 COX15 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63GTVSLPSKAAERVVGubiquitination[1]
109WHLIKEMKPPTSQEEubiquitination[1]
131YQQFPEFKILNHDMTubiquitination[1]
209VKSGLEEKSDSHDIPubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May be involved in the biosynthesis of heme A. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Leigh syndrome; Membrane; Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 410 AA 
Protein Sequence
MQRLLFPPLR ALKGRQYLPL LAPRAAPRAQ CDCIRRPLRP GQYSTISEVA LQSGRGTVSL 60
PSKAAERVVG RWLLVCSGTV AGAVILGGVT RLTESGLSMV DWHLIKEMKP PTSQEEWEAE 120
FQRYQQFPEF KILNHDMTLT EFKFIWYMEY SHRMWGRLVG LVYILPAAYF WRKGWLSRGM 180
KGRVLALCGL VCFQGLLGWY MVKSGLEEKS DSHDIPRVSQ YRLAAHLGSA LVLYCASLWT 240
SLSLLLPPHK LPETHQLLQL RRFAHGTAGL VFLTALSGAF VAGLDAGLVY NSFPKMGESW 300
IPEDLFTFSP ILRNVFENPT MVQFDHRILG ITSVTAITVL YFLSRRIPLP RRTKMAAVTL 360
LALAYTQGPV LFNFTFKISD LDEGIRNI 388 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005746; C:mitochondrial respiratory chain; TAS:UniProtKB.
 GO:0004129; F:cytochrome-c oxidase activity; TAS:UniProtKB.
 GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
 GO:0006784; P:heme a biosynthetic process; IGI:HGNC.
 GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IC:HGNC.
 GO:0008535; P:respiratory chain complex IV assembly; IMP:HGNC.
 GO:0007585; P:respiratory gaseous exchange; TAS:UniProtKB. 
Interpro
 IPR003780; HemeA_syn.
 IPR023754; HemeA_Synthase_type2.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF02628; COX15-CtaA 
SMART
  
PROSITE
  
PRINTS