| Tag | Content |
|---|
| CPLM ID | CPLM-010241 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-succinylglutamate 5-semialdehyde dehydrogenase |
Protein Synonyms/Alias | Succinylglutamic semialdehyde dehydrogenase; SGSD |
Gene Name | astD |
Gene Synonyms/Alias | ydjU; b1746; JW5282 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 110 | NKIAISIKAYHVRTG | acetylation | [1] | | 414 | LVSPEREKFDQLLLE | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. Also shows activity with decanal or succinic semialdehyde as the electron donor and NAD as the electron acceptor. No activity is detected with NADP as the electron acceptor. Therefore, is an aldehyde dehydrogenase with broad substrate specificity. |
Sequence Annotation | NP_BIND 220 225 NAD (By similarity).
ACT_SITE 243 243 By similarity.
ACT_SITE 277 277 By similarity. |
Keyword | Arginine metabolism; Complete proteome; NAD; Oxidoreductase; Reference proteome; Stress response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 492 AA |
Protein Sequence | MTLWINGDWI TGQGASRVKR NPVSGEVLWQ GNDADAAQVE QACRAARAAF PRWARLSFAE 60
RHAVVERFAA LLESNKAELT AIIARETGKP RWEAATEVTA MINKIAISIK AYHVRTGEQR 120
SEMPDGAASL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTIIFKPS ELTPWSGEAV 180
MRLWQQAGLP PGVLNLVQGG RETGQALSAL EDLDGLLFTG SANTGYQLHR QLSGQPEKIL 240
ALEMGGNNPL IIDEVADIDA AVHLTIQSAF VTAGQRCTCA RRLLLKSGAQ GDAFLARLVA 300
VSQRLTPGNW DDEPQPFIGG LISEQAAQQV VTAWQQLEAM GGRPLLAPRL LQAGTSLLTP 360
GIIEMTGVAG VPDEEVFGPL LRVWRYDTFD EAIRMANNTR FGLSCGLVSP EREKFDQLLL 420
EARAGIVNWN KPLTGAASTA PFGGIGASGN HRPSAWYAAD YCAWPMASLE SDSLTLPATL 480
NPGLDFSDEV VR 492 |
Gene Ontology | GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IDA:EcoCyc. GO:0043824; F:succinylglutamate-semialdehyde dehydrogenase activity; IEA:EC. GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP. GO:0019545; P:arginine catabolic process to succinate; IEA:UniProtKB-UniPathway. GO:0006950; P:response to stress; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |