CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006888
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Increased sodium tolerance protein 2 
Protein Synonyms/Alias
  
Gene Name
 IST2 
Gene Synonyms/Alias
 YBR086C; YBR0809 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
402GPNPNFVKAESEIGKubiquitination[1]
409KAESEIGKAQLSSSDubiquitination[1]
630EFNSNNEKELVQRKGubiquitination[1]
695SSKTGVVKAVDNDTAubiquitination[1]
707DTAGSAGKKPLATESubiquitination[1]
708TAGSAGKKPLATESTubiquitination[1]
756LRFDEDGKSIRDAKSubiquitination[1]
762GKSIRDAKSSAESSNubiquitination[1]
781NTLGTESKLLPDGDAubiquitination[1]
816NNENTQAKDDAATKTubiquitination[1]
832LIKDANIKPVVNAAVubiquitination[1]
845AVNDNQSKVSVATEQubiquitination[1]
910RHRDAGVKNVTNNSKubiquitination[1]
917KNVTNNSKTTESSSSubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 May be involved in ion homeostasis together with BTN1 or BTN2. 
Sequence Annotation
 MOD_RES 638 638 Phosphoserine.
 MOD_RES 701 701 Phosphothreonine.
 MOD_RES 704 704 Phosphoserine.
 MOD_RES 720 720 Phosphoserine.
 MOD_RES 726 726 Phosphothreonine.
 MOD_RES 729 729 Phosphoserine.
 MOD_RES 730 730 Phosphotyrosine.
 MOD_RES 757 757 Phosphoserine.
 MOD_RES 793 793 Phosphoserine.
 MOD_RES 844 844 Phosphoserine.
 MOD_RES 847 847 Phosphoserine.
 MOD_RES 850 850 Phosphothreonine.  
Keyword
 Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 946 AA 
Protein Sequence
MSQTITSLDP NCVIVFNKTS SANEKSLNVE FKRLNIHSII EPGHDLQTSY AFIRIHQDNA 60
KPLFSFLQNL DFIESIIPYH DTELSDDLHK LISISKSKIL EAPKQYELYN LSNLTNNPKQ 120
SLYFAFLQNY IKWLIPFSFF GLSIRFLSNF TYEFNSTYSL FAILWTLSFT AFWLYKYEPF 180
WSDRLSKYSS FSTIEFLQDK QKAQKKASSV IMLKKCCFIP VALLFGAILL SFQLYCFALE 240
IFIKQIYNGP MISILSFLPT ILICTFTPVL TVIYNKYFVE PMTKWENHSS VVNAKKSKEA 300
KNFVIIFLSS YVPLLITLFL YLPMGHLLTA EIRTKVFNAF SILARLPTHD SDFIIDTKRY 360
EDQFFYFIVI NQLIQFSMEN FVPSLVSIAQ QKINGPNPNF VKAESEIGKA QLSSSDMKIW 420
SKVKSYQTDP WGATFDLDAN FKKLLLQFGY LVMFSTIWPL APFICLIVNL IVYQVDLRKA 480
VLYSKPEYFP FPIYDKPSSV SNTQKLTVGL WNSVLVMFSI LGCVITATLT YMYQSCNIPG 540
VGAHTSIHTN KAWYLANPIN HSWINIVLYA VFIEHVSVAI FFLFSSILKS SHDDVANGIV 600
PKHVVNVQNP PKQEVFEKIP SPEFNSNNEK ELVQRKGSAN EKLHQELGEK QPASSANGYE 660
AHAATHANND PSSLSSASSP SLSSSSSSSK TGVVKAVDND TAGSAGKKPL ATESTEKRNS 720
LVKVPTVGSY GVAGATLPET IPTSKNYYLR FDEDGKSIRD AKSSAESSNA TNNNTLGTES 780
KLLPDGDAVD ALSRKIDQIP KIAVTGGENN ENTQAKDDAA TKTPLIKDAN IKPVVNAAVN 840
DNQSKVSVAT EQTKKTEVST KNGPSRSIST KETKDSARPS NNNTTTTTTT DATQPHHHHH 900
HHRHRDAGVK NVTNNSKTTE SSSSSSAAKE KPKHKKGLLH KLKKKL 946 
Gene Ontology
 GO:0033101; C:cellular bud membrane; IDA:SGD.
 GO:0032541; C:cortical endoplasmic reticulum; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0008289; F:lipid binding; IDA:SGD.
 GO:0090158; P:endoplasmic reticulum membrane organization; IGI:SGD.
 GO:0060304; P:regulation of phosphatidylinositol dephosphorylation; IGI:SGD. 
Interpro
 IPR007632; Anoctamin. 
Pfam
 PF04547; Anoctamin 
SMART
  
PROSITE
  
PRINTS