CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042341
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase UBR3 
Protein Synonyms/Alias
  
Gene Name
 UBR3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70PETAPEVKRDSPASTubiquitination[1]
102SLVAERRKKFQEIINubiquitination[2]
103LVAERRKKFQEIINRubiquitination[1, 2, 3]
199AVERILLKAASQSRMubiquitination[1, 2, 3]
332RDNVEPKKLPISEEEubiquitination[2]
448PWQRPSNKSIQDLIKubiquitination[2]
542GGASTAGKRSCLNQLubiquitination[1, 2]
795ERHAEQGKALLIQESubiquitination[4]
915DRDLRRGKPLYICKEubiquitination[2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 950 AA 
Protein Sequence
XSEHVLCMVL YLIELGLENS AEEESDEEAS VGGPERCHDS WFPGSNLVSN MRHFINYVRV 60
RVPETAPEVK RDSPASTSSD NLGSLQNSGT AQVFSLVAER RKKFQEIINR SSSEANQVVR 120
PKTSSKWSAP GSAPQLTTAI LEIKESILSL LIKLHHKLSG KQNSYYPPWL DDIEILIQPE 180
IPKYSHGDGI TAVERILLKA ASQSRMNKRI IEEICRKVTP PVPPKKVTAA EKKTLDKEER 240
RQKARERQQK LLAEFASRQK SFMETAMDVD SPENDIPMEI TTAEPQVSEA VYDCVICGQS 300
GPSSEDRPTG LVVLLQASSV LGQCRDNVEP KKLPISEEEQ IYPWDTCAAV HDVRLSLLQR 360
YFKDSSCLLA VSIGWEGGVY VQTCGHTLHI DCHKSYMESL RNDQVLQGFS VDKGEFTCPL 420
CRQFANSVLP CYPGSNVENN PWQRPSNKSI QDLIKEVEEL QGRPGAFPVS ISSETNLSKE 480
MESVMKDIKN TTQKKYRDYS KTPGSPDNDF LFMYSVARTN LELELIHRGG NLCSGGASTA 540
GKRSCLNQLF HVLALHMRLY SIDSEYNPWR KLTQLEEMNP QLGYEEQQPE VPILYHDVTS 600
LLLIQILMMP QPLRKDHFTC IVKVLFTLLY TQALAALSVK CSEEDRSAWK HAGALKKSTC 660
DAEKSYEVLL SFVISELFKG KLYHEEGTQE CAMVNPIAWS PESMEKCLQD FCLPFLRITS 720
LLQHHLFGED LPSCQEEEEF SVLASCLGLL PTFYQTEHPF ISASCLDWPV PAFDIITQWC 780
FEIKSFTERH AEQGKALLIQ ESKWKLPHLL QLPENYNTIF QYYHRKTCSV CTKVPKDPAV 840
CLVCGTFVCL KGLCCKQQSY CECVLHSQNC GAGTGIFLLI NASVIIIIRG HRFCLWGSVY 900
LDAHGEEDRD LRRGKPLYIC KERYKVLEQQ WISHTFDHIN KRWGPHYNGL 950 
Gene Ontology
  
Interpro
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
  
SMART
  
PROSITE
  
PRINTS